Ceralasertib (AZD6738) - Moligand™, 10mM in DMSO , Inhibitor of ATR serine/threonine kinase, CAS No.1352226-88-0, Inhibitor of ATR serine/threonine kinase

CAS: 1352226-88-0 Cat. No.: C408010 Peso molecular: 412.51 Número EC: 805-672-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Ceralasertib (AZD6738) is an orally active, and selectiveATRkinase inhibitor withIC50of 1 nM. Phase 1/2.
In vitro

In four Kras mutant cell lines: H23, H460, A549, and H358, AZD6738 inhibits ATR kinase activity and impairs cell viability. In ATM-deficient H23 cells, AZD6738 strongly synergizes with cisplatin to induce rapid cell death. In p53 or ATM defective cells, AZD6738 treatment results in replication fork stalls and accumulation of unrepaired DNA damage, resulting in cell death by mitotic catastrophe.

In vivo

In nude mice bearing H460 and H23 tumors, AZD6738 (50 mg/kg, p.o.) results in tumor growth inhibition (TGI), and the the combination with cisplatin causes rapid regression of ATM-deficient H23 tumors. In nude mice bearing LoVo xenografts, a combination of AZD6738 (50\u2009mg/kg)\u2009+\u2009IR (2\u2009Gy) avoids toxicity while still maintaining efficacy.
Cell Data

cell lines：MDA-MB-231 cell line

Concentrations：~30 μM

Incubation Time：48 h

Powder Purity:≥99%

Specifications

Sinónimos

4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2, 3-b]pyridine

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. Phase 1/2.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of ATR serine/threonine kinase

Propiedades del producto

• ALogP: 2.427
• hba_count: 5
• Recuento HBD: 1
• Enlace rotable: 4

Nombres e identificadores

• Isómeros SMILES: C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)[S@](=N)(=O)C)C4=C5C=CNC5=NC=C4
• CAS alternativo: 1352226-88-0
• Términos de entrada MeSH: 4-(4-(1-((S(R))-S-methylsulfonimidoyl)cyclopropyl)-6-((3R)-3-methyl-4-morpholinyl)-2-pyrimidinyl)-1H-pyrrolo(2,3-b)pyridine;AZD-6738;AZD6738;ceralasertib
• Peso molecular: 412.51
• Reaxy-Rn: 31199993
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31199993&ln=

Objetivos asociados (humanos)

ATR Tchem Serine/threonine-protein kinase ATR (2 Activities)

Discover Target: ATR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 55 mg/mL (198.26 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/ml) Solubilidad máxima: 82
• DMSO (mM) Solubilidad máxima: 198.7830598
• Agua (mg/ml) Solubilidad máxima: ＜1