CFTRinh-172 - 10mM in DMSO , CAS No.307510-92-5

CAS: 307510-92-5 Cat. No.: C408961 Peso molecular: 409.4 Número EC: 636-554-0

GRADE & PURITY 10mM in DMSO

Synonyms

CFTR inhibitor 172 | Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

CFTRinh-172 CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with K i of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.
In vitro

CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I^- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl⁻ current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition.

In vivo

CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo.
Cell Data

cell lines：Rheumatoid arthritis synovial fibroblast(s)

Concentrations：~1 mM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Sinónimos

CFTR inhibitor 172 | Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with K_i of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F
• WGK Alemania: 3
• Peso molecular: 409.4
• Reaxy-Rn: 9949257
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9949257&ln=

Objetivos asociados (humanos)

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (3 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)