Chlorisondamine diiodide - ≥99%(HPLC) , CAS No.96750-66-2

CAS: 96750-66-2 Cat. No.: C286788 Peso molecular: 611.95 Número EC: 635-559-5 PubChem CID: 16078959

GRADE & PURITY ≥99%(HPLC)

Synonyms

Chlorisondamine diiodide, >=98% (HPLC), white solid | trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-1,3-dihydroisoindol-2-ium-2-yl)ethyl]azanium;diiodide | 4,5,6,7-tetrachloro-2-methyl-2-(2-(trimethylammonio)ethyl)isoindolinium iodide | HMS3678J05 | 4,5,6,7-

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

Chlorisondamine (diiodide) is a potent nicotinic acetylcholine receptor (nAChR) antagonist and a ganglion blocker. Chlorisondamine antagonizes some of nicotine's central actions in a potent, long-lasting and pharmacologically selective way.

Product Application:

Chlorisondamine diiodide has been used:
as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress.

Specifications

Sinónimos

Chlorisondamine diiodide, >=98% (HPLC), white solid | trimethyl-[2-(4, 5, 6, 7-tetrachloro-2-methyl-1, 3-dihydroisoindol-2-ium-2-yl)ethyl]azanium;diiodide | 4, 5, 6, 7-tetrachloro-2-methyl-2-(2-(trimethylammonio)ethyl)isoindolinium iodide | HMS3678J05 | 4, 5, 6, 7-

Especificaciones y pureza

≥99%(HPLC)

Mecanismos bioquímicos y fisiológicos

An exceptionally long lasting nicotinic antagonist (IC50~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Pureza

≥99%(HPLC)

Nombres e identificadores

• Sonrisas canónicas: C[N+]1(CC2=C(C1)C(=C(C(=C2Cl)Cl)Cl)Cl)CC[N+](C)(C)C.[I-].[I-]
• IUPAC Name: trimethyl-[2-(4,5,6,7-tetrachloro-2-methyl-1,3-dihydroisoindol-2-ium-2-yl)ethyl]azanium;diiodide
• InChIKey: FPNVAOZHQUJJJQ-UHFFFAOYSA-L
• INCHI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• Isómeros SMILES: C[N+]1(CC2=C(C1)C(=C(C(=C2Cl)Cl)Cl)Cl)CC[N+](C)(C)C.[I-].[I-]
• WGK Alemania: 2
• PubChem CID: 16078959
• Peso molecular: 611.95

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Isoindoles and derivatives
      • Subclass Isoindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Isoindoles and derivatives
• Subclass: Isoindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Isoindoles
• Alternative Parents: Isoindolines Aralkylamines Benzenoids Aryl chlorides Tetraalkylammonium salts Azacyclic compounds Organochlorides Organic iodide salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Isoindoline - Isoindole - Aralkylamine - Benzenoid - Aryl halide - Aryl chloride - Quaternary ammonium salt - Tetraalkylammonium salt - Azacycle - Organic iodide salt - Amine - Organic salt - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic cation - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as isoindoles. These are heteropolycyclic compounds with a structure containing isoindole, a benzo-fused pyrrole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solvent:water, Max Conc. mg/mL: 6.12, Max Conc. mM: 10
• Sensibilidad: light sensitive
• Peso molecular: 611.900 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 611.844 Da
• Monoisotopic Mass: 609.847 Da
• Topological Polar Surface Area: 0.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 336.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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