≥85% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 53 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Chondroitin Sulfate (CS) is a type of sulfated GAGs composed of disaccharide units (GlcUA β 1-3GalNAc) composed of glucuronic acid (GlcUA) and N-acetylgalactosamine (GalNAc), which are repeatedly linked by β -1,4-glycosidic bonds. In the process of biosynthesis, the chondroitin basic skeleton of CS (-4GlcA β 1-3GalNAc β 1-) is first synthesized on specific serine residues of the core protein. During this process, the C6 and C-4 of GalNAc and the C2 of GlcA undergo sulfation modifications in the sugar chain by various sulfate transferases, forming disaccharide units with multiple different and sulfation modes. CS from different animal tissue sources are usually named based on the main disaccharide units they contain or the rare disaccharide units they are rich in, such as CS-A from mammalian cartilage, which mainly contains the 4-O-sulfated disaccharide GlcA β 1-3GalNAc (4S) (A unit); The CS-C derived from shark cartilage mainly contains the 6-O-sulfated disaccharide GlcA β 1-3GalNAc (6S) (C unit); CS-D derived from shark wings is rich in rare 2,6-O-sulfated disaccharide GlcA (2S) β 1-3GalNAc (6S) (D unit); CS-E derived from squid cartilage is rich in rare 4,6-O-sulfated disaccharide GlcA β 1-3GalNAc (4S, 6S) (E unit). In addition, common disaccharide units include trisulfated disaccharide T units (GlcA (2S) β 1-3GalNAc (4S, 6S)). These sulfation modifications make the composition and structure of CS highly complex, and endow it with diverse biological functions, such as participating in various physiological and pathological processes such as nervous system development, cell division, cell differentiation, cell signal transduction, morphogenesis, and inflammation.
| Sonrisas canónicas | CC(=O)NC1C(C(C(OC1O)OS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)O |
|---|---|
| IUPAC Name | (2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| InChIKey | KXKPYJOVDUMHGS-OSRGNVMNSA-N |
| INCHI | 1S/C13H21NO15S/c1-2(15)14-3-8(7(19)13(28-11(3)22)29-30(23,24)25)26-12-6(18)4(16)5(17)9(27-12)10(20)21/h3-9,11-13,16-19,22H,1H3,(H,14,15)(H,20,21)(H,23,24,25)/t3-,4+,5+,6-,7-,8-,9+,11-,12-,13-/m1/s1 |
| Isómeros SMILES | CC(=O)N[C@@H]1[C@H]([C@H]([C@H](O[C@H]1O)OS(=O)(=O)O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O |
| WGK Alemania | 3 |
| CAS alternativo | 9007-28-7 |
| Reaxy-Rn | 29675846 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29675846&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Clase | Organooxygen compounds |
| Subclass | Carbohydrates and carbohydrate conjugates |
| Intermediate Tree Nodes | Sugar acids and derivatives - Glucuronic acid derivatives - Glucuronides |
| Direct Parent | O-glucuronides |
| Alternative Parents | Disaccharides O-glycosyl compounds Beta hydroxy acids and derivatives Alkyl sulfates Sulfuric acid monoesters Oxanes Pyrans Acetamides Secondary alcohols Hemiacetals Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Oxacyclic compounds Acetals Polyols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic heteromonocyclic compounds |
| Substituents | 1-o-glucuronide - O-glucuronide - Disaccharide - Glycosyl compound - O-glycosyl compound - Beta-hydroxy acid - Hydroxy acid - Oxane - Pyran - Sulfuric acid monoester - Sulfate-ester - Alkyl sulfate - Sulfuric acid ester - Acetamide - Organic sulfuric acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Hemiacetal - Oxacycle - Monocarboxylic acid or derivatives - Acetal - Carboxylic acid - Organoheterocyclic compound - Carboxylic acid derivative - Polyol - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Organonitrogen compound - Alcohol - Aliphatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as o-glucuronides. These are glucuronides in which the aglycone is linked to the carbohydrate unit through an O-glycosidic bond. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 F2517284 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| F2517295 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| F2517301 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| F2517302 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| F2517303 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| F2517304 | Certificate of Analysis | Jun 26, 2025 | C758469 |
| Solubilidad | Soluble in water ; it is almost insoluble in acetone and 96 % ethanol. |
|---|---|
| Sensibilidad | Moisture sensitive |
| Rotación específica [α] | -20~-30 |
| Punto de fusión (°C) | >150℃ |
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| 2. Jiaye Li, Fengyuan Wang, Youjun Ding, Guopu Chen, Qian Tan, Yuanjin Zhao. (2025) Biomimetic ECM hydrogels loaded with ADSCs and polydopamine nanoparticles for chronic wound healing. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.160764] |
| 3. Xi Yuan, Guanghao Li, Long Huang, Meng Zheng, Jin Su, Junlai Wan, Haozhe Cheng, Hao Zhu, Xulin Jiang, Jun Xiao. (2024) Hydroxypropyl Chitin-Oxidized chondroitin sulfate double-network hydrogel assists microfracture technique to enhance cartilage regeneration. MATERIALS & DESIGN, [PMID:] [10.1016/j.matdes.2024.112656] |
| 4. Yuxia Liu, Ming Wei, Guo Li, Yilong Zhao, Xiuzhen Yan, Shukai Wang, Xuezheng Song, Zhongfu Wang, Linjuan Huang. (2025) Isolation, structural characterization of natural chondroitin sulfate oligosaccharides and their binding study with anti-angiogenic factors. CARBOHYDRATE POLYMERS, [PMID:39914977] [10.1016/j.carbpol.2025.123262] |
| 5. Yanyan Wang, Ruyu Yan, Hai Yang, Ying Liu, Xiupeng Zhong, Sa Liu, Renjian Xie, Li Ren. (2024) Modular microgel-based bioassembly scaffold induced chondrogenic and osteogenic differentiation of BMSCs. MACROMOLECULAR BIOSCIENCE, [PMID:38663437] [10.1002/mabi.202400051] |
| 6. Chenci Xu, Weiqi Li, Jing Mao, Ziyang Liu, An Lao, Lixia Mao, Anqi Gu, Jiaqing Wu, Aili Shen, Kaili Lin, Jiaqiang Liu. (2024) Using chondroitin sulfate lithium hydrogel for diabetic bone regeneration via regulation of macrophage polarization. CARBOHYDRATE POLYMERS, [PMID:39487003] [10.1016/j.carbpol.2024.122787] |
| 7. Zhang Hugang, Jia Jiaxin, Liu Hanyu, Han Haobo, Li Quanshun. (2025) Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis. Nature Communications, 16 (1): (1-21). [PMID:40676021] [10.1038/s41467-025-61923-7] |
| 8. Xinyi Zhou, Siyu Fang, Luoyan Lin, Hao Feng, Tianyu Li, Lu Fang. (2025) Development of an electrochemical sensor for heparin utilizing PEDOT:PSS/AuNPs nanocomposites. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114480] |
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| 10. Yufan Shi, Shuang Rong, Tingxian Guo, Ruyi Zhang, Duoxia Xu, Yahong Han, Fuguo Liu, Jiaqi Su, Hongxin Xu, Shuai Chen. (2023) Fabrication of compact zein-chondroitin sulfate nanocomplex by anti-solvent co-precipitation: Prevent degradation and regulate release of curcumin. FOOD CHEMISTRY, [PMID:37562259] [10.1016/j.foodchem.2023.137110] |
| 11. Lili Jin, Miao He, Ying Chen, Changsheng Liu, Hongyan He. (2023) Reverse milling–sputtering technology to develop scalable microneedle patches for analgesia. Materials Today Communications, [PMID:] [10.1016/j.mtcomm.2023.106611] |
| 12. Yue Zhuo, Yuehui Liang, Duoxia Xu, David Julian McClements, Suqing Wang, Qi Li, Yahong Han, Fuguo Liu, Shuai Chen. (2023) Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37257529] [10.1016/j.ijbiomac.2023.125109] |
| 13. Yuan Zhang, Wenjuan Chen, Wenjing Feng, Wenhong Fang, Xiao Han, Cui Cheng. (2023) Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation. CARBOHYDRATE POLYMERS, [PMID:37173033] [10.1016/j.carbpol.2023.120937] |
| 14. Wenhao Wang, Ao Wang, Gaofu Hu, Mengyao Bian, Lili Chen, Qian Zhao, Weilian Sun, Yanmin Wu. (2023) Potential of an Aligned Porous Hydrogel Scaffold Combined with Periodontal Ligament Stem Cells or Gingival Mesenchymal Stem Cells to Promote Tissue Regeneration in Rat Periodontal Defects. ACS Biomaterials Science & Engineering, [PMID:36942823] [10.1021/acsbiomaterials.2c01440] |
| 15. Zuwu Tang, Meiqiong Yu, Ajoy Kanti Mondal, Xinxing Lin. (2023) Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels. Polymers, 15 (2): (271). [PMID:36679152] [10.3390/polym15020271] |
| 16. Jiaqian Zhu, Huihui Yuan, Shunqi Zhang, Xiang Hao, Minbo Lan. (2022) Construction of antifouling and antibacterial polyhexamethylguanidine/chondroitin sulfate coating on polyurethane surface based on polydopamine rapid deposition. JOURNAL OF APPLIED POLYMER SCIENCE, 139 (42): (e53009). [PMID:] [10.1002/app.53009] |
| 17. Min Cai, Xiaojun Li, Meng Xu, Shiqi Zhou, Lei Fan, Jingyan Huang, Cairong Xiao, Yichen Lee, Bo Yang, Le Wang, Ross William Crawford, Yin Xiao, Lei Zhou, Chengyun Ning, Yan Wang. (2022) Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.138086] |
| 18. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180] |
| 19. Decheng Zhang, Xiudan Lang, Ni Hui, Jiasheng Wang. (2022) Dual-Mode electrochemical biosensors based on Chondroitin sulfate functionalized polypyrrole nanowires for ultrafast and ultratrace detection of acetamiprid pesticide. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2022.107530] |
| 20. Zhang Hongzhen, Xu Ronghua, Yin Zuowen, Yu Jun, Liang Ning, Geng Qian. (2021) Drug-Loaded Chondroitin Sulfate Microspheres Generated from Microfluidic Electrospray for Wound Healing. MACROMOLECULAR RESEARCH, 30 (1): (36-42). [PMID:] [10.1007/s13233-022-0001-4] |
| 21. Shanshan Xu, Chunyu Liu, Shuya Zang, Jiaxin Li, Yashi Wang, Kebai Ren, Man Li, Zhirong Zhang, Qin He. (2021) Multifunctional self-delivery micelles targeting the invasion-metastasis cascade for enhanced chemotherapy against melanoma and the lung metastasis. Asian Journal of Pharmaceutical Sciences, [PMID:35027954] [10.1016/j.ajps.2021.08.002] |
| 22. Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen, Zhiyu Zhou, Shaoyu Liu. (2021) Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Oxidative Medicine and Cellular Longevity, [PMID:34512867] [10.1155/2021/5608133] |
| 23. He Yang, Zhifang Ma, Xinghua Guan, Zehong Xiang, Yue Ke, Yu Xia, Zhirong Xin, Qiang Shi, Jinghua Yin. (2021) Facile fabrication of diatomite-based sponge with high biocompatibility and rapid hemostasis. JOURNAL OF APPLIED POLYMER SCIENCE, 138 (46): (51360). [PMID:] [10.1002/app.51360] |
| 24. Shouwei Zhang, Liu Yang, Dong Ding, Pengcheng Gao, Fan Xia, Merlin L. Bruening. (2021) Highly Rectifying Fluidic Diodes Based on Asymmetric Layer-by-Layer Nanofilms on Nanochannel Membranes. ANALYTICAL CHEMISTRY, [PMID:33625211] [10.1021/acs.analchem.0c05303] |
| 25. Lei Zhou, Lei Fan, Feng-Miao Zhang, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng, Aldo R. Boccaccini, Guo-Xin Tan. (2020) Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation. Bioactive Materials, [PMID:33073063] [10.1016/j.bioactmat.2020.09.012] |
| 26. Aijiao Zhou, Xumeng Wu, Wangwei Chen, Lei Liao, Pengchao Xie. (2020) Fabrication of hydrophobic/hydrophilic bifunctional adsorbent for the removal of sulfamethoxazole and bisphenol A in Water. Journal of Environmental Chemical Engineering, [PMID:] [10.1016/j.jece.2020.104161] |
| 27. Xiqi Ma, Xiaojuan Wang, Qi Chen, Hua He, Yixin Sun, Hui Liu, Yanan Wang, Jianbo Qu, Fang Huang. (2019) Glycosaminoglycan / gold nanocluster hybrid nanoparticles as a new sensing platform: Metastatic potential assessment of cancer cells. CARBOHYDRATE POLYMERS, [PMID:31887958] [10.1016/j.carbpol.2019.115654] |
| 28. Feng-Miao Zhang, Lei Zhou, Zheng-Nan Zhou, Cong Dai, Lei Fan, Chang-Hao Li, Cai-Rong Xiao, Cheng-Yun Ning, Yi Liu, Jian-Qiang Du, Guo-Xin Tan. (2019) Bioactive glass functionalized chondroitin sulfate hydrogel with proangiogenic properties. BIOPOLYMERS, 110 (12): (e23328). [PMID:31454076] [10.1002/bip.23328] |
| 29. Xiaozhi Ren, Jinxiu Li, Jiayi Li, Yuqi Jiang, Lan Li, Qingqiang Yao, Qinfei Ke, He Xu. (2019) Aligned porous fibrous membrane with a biomimetic surface to accelerate cartilage regeneration. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2019.03.271] |
| 30. Yingying Qi, Jiahuan He, Fu-Rong Xiu, Xuan Yu, Yifan Li, Yongwei Lu, Xiang Gao, Zhiqi Song, Baoxin Li. (2019) A facile chemiluminescence sensing for ultrasensitive detection of heparin using charge effect of positively-charged AuNPs. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:30909087] [10.1016/j.saa.2019.03.073] |
| 31. Qing Liu, Xu Yan, Qi Lai, Xingguang Su. (2018) Bimetallic gold/silver nanoclusters-gold nanoparticles based fluorescent sensing platform via the inner filter effect for hyaluronidase activity detection. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2018.11.040] |
| 32. Liang Si-Si, Deng Xu, Fan Yao-Yao, Li Jun, Wang Man, Zhang Zhi-Qi. (2018) A ratiometric fluorometric heparin assay based on the use of CdTe and polyethyleneimine-coated carbon quantum dots. MICROCHIMICA ACTA, 185 (11): (1-7). [PMID:30361934] [10.1007/s00604-018-3061-6] |
| 33. Qu Fei, Li Xiaonan, Lv Xiaoxia, You Jinmao, Han Wenli. (2018) Highly selective metal–organic framework-based sensor for protamine through photoinduced electron transfer. JOURNAL OF MATERIALS SCIENCE, 54 (4): (3144-3155). [PMID:] [10.1007/s10853-018-3041-6] |
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| 35. Huang Jianyong, Li Fenglan, Guo Rubin, Chen Yuyuan, Wang Zhenzhen, Zhao Chengfei, Zheng Yanjie, Weng Shaohuang, Lin Xinhua. (2018) A signal-on ratiometric fluorometric heparin assay based on the direct interaction between amino-modified carbon dots and DNA. MICROCHIMICA ACTA, 185 (5): (1-9). [PMID:29680977] [10.1007/s00604-018-2798-2] |
| 36. Fei Qu, Yanqun Liu, Haili Lao, Yaping Wang, Jinmao You. (2017) Colorimetric detection of heparin with high sensitivity based on the aggregation of gold nanoparticles induced by polymer nanoparticles. NEW JOURNAL OF CHEMISTRY, 41 (19): (10592-10597). [PMID:] [10.1039/C7NJ02381B] |
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| 46. Qinying Yan, Shulin Shen, Linxiao Liu, Jiaqi Weng, Gensuo Zheng, Xu Dong, Jing Yang, Qingliang Yang, Jing Xie. (2024) Fabrication of controlled porous and ultrafast dissolution porous microneedles by organic-solvent-free ice templating method. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:38734274] [10.1016/j.ijpharm.2024.124220] |
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| 49. Wenyan Gao, Shaochun Li, Ya Miao, Guangfu Yuan, Gaoyang Li, Guoqiang Zhou, Guang Jia, Xinjian Yang, Yi Jin. (2025) Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated ‘outside-in’ and ‘inside-out’ strategy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:40252578] [10.1016/j.jcis.2025.137612] |
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| 51. Yishan Chen, Wei Sun, Ya Wen, Xiaozhao Wang, Jiachen Li, Shaofang Xie, Rui Li, Yuanzhu Ma, Hongwei Wu, Qiuwen Zhu, Ziheng Chen, Xianzhu Zhang, Youguo Liao, Junxin Lin, Wenyue Li, Yiyang Yan, Dingchao Ying, Qiulin He, Hongxu Meng, Chong Teng, Wenyan Zhou, Yong Wang, Xu Li, Zi Yin, Wei Wei, Kam W. Leong, Hongwei Ouyang. (2025) A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy. Science Translational Medicine, 17 (804): [PMID:40561002] [10.1126/scitranslmed.adl5623] |
| 52. Shulin Shen, Yuxin Liu, Liting Wang, Jiaqi Weng, Binghui Xie, Yueyue Xie, Xuechao Chen, Qingqing Huo, Xiaohe Chu, Yunxiang Zhang, Meselhy R. Meselhy Zayed, Qinying Yan. (2025) Achieving rapid and precisely controllable drug loading via spontaneous imbibition in porous microneedles: mechanistic and optimization strategies. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:41325831] [10.1016/j.ijpharm.2025.126430] |
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