cis-Resveratrol - ≥95% , CAS No.61434-67-1

CAS: 61434-67-1 Cat. No.: R275663 Peso molecular: 228.25 Número EC: 694-803-9

GRADE & PURITY ≥95%

Synonyms

4q93 | (Z)-3,5,4'-trihydroxystilbene | 05F9DB2A-D7E6-4063-8E5B-F7842CF74A5E | BDBM50131698 | Cis resveratrol | Lopac-R-5010 | NCGC00015894-02 | CAS-501-36-0 | TNP00294 | (Z)-3,4',5-trihydroxystilbene | Q27116664 | AC-24235 | cis-3,5,4'-trihydroxystilbene

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

4q93 | (Z)-3, 5, 4'-trihydroxystilbene | 05F9DB2A-D7E6-4063-8E5B-F7842CF74A5E | BDBM50131698 | Cis resveratrol | Lopac-R-5010 | NCGC00015894-02 | CAS-501-36-0 | TNP00294 | (Z)-3, 4', 5-trihydroxystilbene | Q27116664 | AC-24235 | cis-3, 5, 4'-trihydroxystilbene

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

Antioxidant agent. NADPH oxidase inhibitor. Blocks ROS production. Resveratrol isomer. Inhibits canonical and non-canonical inflammasomes in macrophages. Shows anti-inflammatory and antiproliferative effects.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504760578
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504760578
• Sonrisas canónicas: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
• IUPAC Name: 5-[(Z)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
• InChIKey: LUKBXSAWLPMMSZ-UPHRSURJSA-N
• INCHI: 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1-
• Isómeros SMILES: C1=CC(=CC=C1/C=C\C2=CC(=CC(=C2)O)O)O
• Peso molecular: 228.25
• Reaxy-Rn: 1912433
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1912433&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Clase Stilbenes

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Clase: Stilbenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Stilbenes
• Alternative Parents: Styrenes Resorcinols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Stilbene - Styrene - Resorcinol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 ) are derived from the common phenylpropene (C6-C3) skeleton building block. The introduction of one or more hydroxyl groups to a phenyl ring lead to stilbenoids.
• External Descriptors: resveratrol

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

CYP1A2 Tchem Cytochrome P450 1A2 (2 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP19A1 Tclin Cytochrome P450 19A1 (6099 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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A498 (42825 Activities)

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BXPC-3 (2997 Activities)

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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MCF7 (126967 Activities)

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OVCAR-3 (48710 Activities)

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SF-295 (48000 Activities)

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SK-BR-3 (5175 Activities)

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SK-MEL-5 (47095 Activities)

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SW480 (6023 Activities)

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HCT-116 (91556 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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KM-20L2 (14967 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

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HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

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POLK Tbio DNA polymerase kappa (8653 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THPO Tbio Thrombopoietin (834 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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PRKD3 Tchem Protein kinase C (PKC) (1010 Activities)

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Objetivos asociados (no humanos)

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

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Plasmodium falciparum (966862 Activities)

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Coxsackievirus B3 (1096 Activities)

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Enterovirus A71 (1246 Activities)

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P388 (20296 Activities)

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RAW264.7 (28094 Activities)

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B16-F10 (4610 Activities)

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lef Anthrax lethal factor (7585 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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Nqo1 NAD(P)H dehydrogenase [quinone] 1 (1058 Activities)

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PYK Pyruvate kinase (6726 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO to 100 mM
• Sensibilidad: Light sensitive；Moisture sensitive
• Peso molecular: 228.240 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 228.079 Da
• Monoisotopic Mass: 228.079 Da
• Topological Polar Surface Area: 60.700 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Shuhui Lei, Kaiqun Liu, Cong Liu, Ran An, Zilu Bao, Huan Zhang, Min Zou, Jianqiu Chen, HuiHui Zhang, Liangkai Wei, Zhou Lan, Lvyi Chen.  (2025)  Cis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca²⁺-phagocytosis-ROS axis.  PHYTOMEDICINE,      [PMID:40812222] [10.1016/j.phymed.2025.157145]