CK-2-68 , CAS No.1361004-87-6

CAS: 1361004-87-6 Cat. No.: C1420183 PubChem CID: 56965336

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase ( NDH2 ) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC 50 of 40 nM.

Specifications

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Sonrisas canónicas: CC1=C(NC2=C(C1=O)C=CC(=C2)Cl)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
• IUPAC Name: 7-chloro-3-methyl-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]phenyl]-1H-quinolin-4-one
• InChIKey: GGVLPENGSGQOOU-UHFFFAOYSA-N
• INCHI: 1S/C24H17ClF3NO2/c1-14-22(29-21-13-18(25)8-11-20(21)23(14)30)17-6-2-15(3-7-17)12-16-4-9-19(10-5-16)31-24(26,27)28/h2-11,13H,12H2,1H3,(H,29,30)
• Isómeros SMILES: CC1=C(NC2=C(C1=O)C=CC(=C2)Cl)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
• PubChem CID: 56965336
• Términos de entrada MeSH: 7-chloro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)phenyl)quinolin-4(1H)-one;CK-2-68

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Phenylquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Phenylquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylquinolines
• Alternative Parents: Diphenylmethanes Phenylpyridines Chloroquinolines Hydroquinolones Hydroquinolines Phenoxy compounds Phenol ethers Methylpyridines Aryl chlorides Vinylogous amides Heteroaromatic compounds Trihalomethanes Azacyclic compounds Organofluorides Organonitrogen compounds Hydrocarbon derivatives Alkyl fluorides Organooxygen compounds Organochlorides Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylquinoline - Diphenylmethane - 2-phenylpyridine - Dihydroquinolone - Chloroquinoline - Haloquinoline - Dihydroquinoline - Phenoxy compound - Phenol ether - Methylpyridine - Aryl chloride - Aryl halide - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Vinylogous amide - Trihalomethane - Azacycle - Organic oxide - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Alkyl fluoride - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Alkyl halide - Hydrocarbon derivative - Halomethane - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y