CK-636 - ≥98%(HPLC) , CAS No.442632-72-6

CAS: 442632-72-6 Cat. No.: C138844 Peso molecular: 284.38 Número EC: 663-254-7

GRADE & PURITY ≥98%(HPLC)

Synonyms

N-(2-(2-Methylindol-3-yl)ethyl)-2-thienylcarboxamide | N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide | DB08235 | STL575917 | HY-15892 | 2-Thiophenecarboxamide, N-(2-(2-methyl-1H-indol-3-yl)ethyl)- | MFCD03036245 | SCHEMBL3612821 | Sulfisomidi

Storage

Room temperature

Shipped In

Normal

Descripción general

CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively

Specifications

Sinónimos

N-(2-(2-Methylindol-3-yl)ethyl)-2-thienylcarboxamide | N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide | DB08235 | STL575917 | HY-15892 | 2-Thiophenecarboxamide, N-(2-(2-methyl-1H-indol-3-yl)ethyl)- | MFCD03036245 | SCHEMBL3612821 | Sulfisomidi

Especificaciones y pureza

≥98%(HPLC)

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Pureza

≥98%(HPLC)

Nombres e identificadores

• Pubchem Sid: 504759396
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504759396
• Sonrisas canónicas: CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CS3
• IUPAC Name: N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
• InChIKey: ACAKNPKRLPMONU-UHFFFAOYSA-N
• INCHI: 1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
• Isómeros SMILES: CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CS3
• WGK Alemania: 3
• Peso molecular: 284.38
• Reaxy-Rn: 19720231
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19720231&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Indoles and derivatives
      • Subclass Indoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Indoles and derivatives
• Subclass: Indoles
• Intermediate Tree Nodes: Not available
• Direct Parent: 3-alkylindoles
• Alternative Parents: Thiophene carboxamides 2-heteroaryl carboxamides Substituted pyrroles Benzenoids Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 3-alkylindole - 2-heteroaryl carboxamide - Thiophene carboxamide - Thiophene carboxylic acid or derivatives - Substituted pyrrole - Benzenoid - Pyrrole - Thiophene - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 3-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 3-position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 284.400 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 284.098 Da
• Monoisotopic Mass: 284.098 Da
• Topological Polar Surface Area: 73.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 349.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1