≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
CL2A-SN38, a drug-linker conjugate, consists of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against various human solid tumor types.
| Sonrisas canónicas | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)OC(=O)OCC5=CC=C(C=C5)NC(=O)C(CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN6C=C(N=N6)CNC(=O)C7CCC(CC7)CN8C(=O)C=CC8=O)C2=NC9=C1C=C(C=C9)O |
|---|---|
| IUPAC Name | [4-[[(2S)-6-amino-2-[[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[[[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetyl]amino]hexanoyl]amino]phenyl]methyl [(19S)-10,19-diethyl-7-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-19-yl] carbonate |
| InChIKey | CMVRBCDBISKHME-URBSQPMJSA-N |
| INCHI | 1S/C73H97N11O22/c1-3-55-56-39-54(85)16-17-60(56)79-67-57(55)44-83-62(67)40-59-58(70(83)92)46-104-71(93)73(59,4-2)106-72(94)105-45-50-10-14-52(15-11-50)77-69(91)61(7-5-6-20-74)78-64(87)48-103-47-63(86)75-21-23-95-25-27-97-29-31-99-33-35-101-37-38-102-36-34-100-32-30-98-28-26-96-24-22-82-43-53(80-81-82)41-76-68(90)51-12-8-49(9-13-51)42-84-65(88)18-19-66(84)89/h10-11,14-19,39-40,43,49,51,61,85H,3-9,12-13,20-38,41-42,44-48,74H2,1-2H3,(H,75,86)(H,76,90)(H,77,91)(H,78,87)/t49?,51?,61-,73-/m0/s1 |
| Isómeros SMILES | CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)OC(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCCN)NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN6C=C(N=N6)CNC(=O)C7CCC(CC7)CN8C(=O)C=CC8=O)C2=NC9=C1C=C(C=C9)O |
| PubChem CID | 89983570 |
| Peso molecular | 1480.61 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Alkaloids and derivatives |
| Clase | Camptothecins |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Camptothecins |
| Alternative Parents | N-acyl-alpha amino acids and derivatives Alpha amino acid amides Hydroxyquinolines Benzyloxycarbonyls Pyranopyridines Anilides N-arylamides 1-hydroxy-2-unsubstituted benzenoids Maleimides Pyridinones N-substituted carboxylic acid imides Carbonic acid diesters Fatty amides Heteroaromatic compounds Pyrrolines Dicarboximides Triazoles Secondary carboxylic acid amides Carboxylic acid esters Lactones Lactams Oxacyclic compounds Monocarboxylic acids and derivatives Dialkyl ethers Azacyclic compounds Carbonyl compounds Monoalkylamines Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Camptothecin - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Hydroxyquinoline - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Pyranopyridine - Quinoline - Anilide - N-arylamide - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Pyridinone - Maleimide - Monocyclic benzene moiety - Carbonic acid diester - Fatty amide - Carboxylic acid imide, n-substituted - Fatty acyl - Pyridine - Benzenoid - 1,2,3-triazole - Pyrroline - Azole - Heteroaromatic compound - Carboxylic acid imide - Dicarboximide - Secondary carboxylic acid amide - Amino acid or derivatives - Carbonic acid derivative - Carboxamide group - Carboxylic acid ester - Lactam - Lactone - Monocarboxylic acid or derivatives - Organoheterocyclic compound - Oxacycle - Ether - Carboxylic acid derivative - Dialkyl ether - Azacycle - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organonitrogen compound - Primary amine - Amine - Organic oxide - Primary aliphatic amine - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring). |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 G2402261 | Certificate of Analysis | Mar 29, 2024 | C412664 |
| G2402263 | Certificate of Analysis | Mar 29, 2024 | C412664 |
| G2402264 | Certificate of Analysis | Mar 29, 2024 | C412664 |
| G2402272 | Certificate of Analysis | Mar 29, 2024 | C412664 |
| G2402273 | Certificate of Analysis | Mar 29, 2024 | C412664 |
| Peso molecular | 1480.600 g/mol |
|---|---|
| XLogP3 | -0.100 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 26 |
| Rotatable Bond Count | 50 |
| Exact Mass | 1479.68 Da |
| Monoisotopic Mass | 1479.68 Da |
| Topological Polar Surface Area | 409.000 Ų |
| Heavy Atom Count | 106 |
| Formal Charge | 0 |
| Complexity | 2930.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
