CLK-IN-T3 - 10mM in DMSO , CAS No.2109805-56-1

CAS: 2109805-56-1 Cat. No.: C655185 Peso molecular: 482.58

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC 50 s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity

In Vitro

CLK-IN-T3 inhibits DYRK1A (IC 50 =260 nM) and DYRK1B (IC 50 =230 nM). CLK-IN-T3 (0.1-10.0 µM; 24 hours) results in mild cell cycle arrest at the G2/M boundary with long-duration (24 h). CLK-IN-T3 (0.5-1.0 µM; 6 hours) decreases phosphorylation of CLK-targeted SR proteins and CLK proteins increase slightly. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: HCT-116 cells Concentration: 0.1, 0.5, 1.0, 5.0, 10.0 µM Incubation Time: 24 hours Result: Resulted in mild cell cycle arrest at the G2/M boundary with long-duration (24 h). Western Blot AnalysisCell Line: HCT-116 cells Concentration: 0.5, 1.0 μM Incubation Time: 6 hours Result: Decreased phosphorylation of CLK-targeted SR proteins and CLK proteins increased slightly.

IC50& Target:CLK1 0.67 nM (IC 50 ) CLK2 15 nM (IC 50 ) CLK3 110 nM (IC 50 ) DYRK1A 260 nM (IC 50 ) DYRK1B 230 nM (IC 50 )

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC 50 s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC(C)(C1=CC=C(C=C1)C(=O)NC2=CN3C=C(C=CC3=N2)C4=CC=NC=C4)C(=O)N5CCN(CC5)C
• Peso molecular: 482.58