GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

CGP9555, CCl 4725 | (11β,​16β)​-21-​chloro-​9-​fluoro-​11-​hydroxy-​16-​methyl-​17-​(1-​oxopropoxy)​-​pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Clobetasol propionate Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

CGP9555, CCl 4725 | (11β, ​16β)​-21-​chloro-​9-​fluoro-​11-​hydroxy-​16-​methyl-​17-​(1-​oxopropoxy)​-​pregna-​1, ​4-​diene-​3, ​20-​dione

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST

Mecanismo de acción

Glucocorticoid receptor agonist

Propiedades del producto

• ALogP: 3.8

Nombres e identificadores

• Isómeros SMILES: CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl
• WGK Alemania: 2
• RTECS: TU3725000
• Peso molecular: 466.97
• Reaxy-Rn: 37811597
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37811597&ln=

Objetivos asociados (humanos)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 (5 Activities)

Discover Target: CYP3A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Rotación específica [α]: +99.0 °～ +103.0°(C=1,Dioxane)
• Punto de fusión (°C): 196.0°C-200.0°C

Referencias

1. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2020)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.126785]

2. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2017)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,      [PMID:29332823] [10.1016/j.talanta.2017.12.071]

3. Guozheng Zhao.  (2023)  Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor.  MOLECULES,  28  (18): (6619).  [PMID:37764395] [10.3390/molecules28186619]

4. Guozheng Zhao.  (2024)  Detection of six glucocorticoids using a nanogold-glucocorticoid receptor-based biosensor.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2024.141611]

5. Guozheng Zhao.  (2025)  Simultaneous detection of four glucocorticoids by graphene-chitosan\ nanogold\glucocorticoid receptor bioimmunosensor.  CHEMICAL PHYSICS LETTERS,      [PMID:] [10.1016/j.cplett.2025.142060]