GRADE & PURITY 10mM in DMSO

Synonyms

Clopidogrel hydrogen sulfate, Iscover, Plavix | Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-, sulfate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Clopidogrel Bisulfate (SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix) is an oral, thienopyridine class antiplatelet agent.
In vitro

Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5.

In vivo

Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP\'s effects provide a marked enhanced antithrombotic efficacy.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Clopidogrel hydrogen sulfate, Iscover, Plavix | Thieno[3, 2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6, 7-dihydro-, methyl ester, (αS)-, sulfate

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Clopidogrel Bisulfate (SR-25990C, Clopidogrel hydrogen sulfate, Iscover, Plavix) is an oral, thienopyridine class antiplatelet agent.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

ANTAGONIST

Mecanismo de acción

Purinergic receptor P2Y12 antagonist

Nombres e identificadores

• Isómeros SMILES: COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.OS(=O)(=O)O
• WGK Alemania: 3
• PubChem CID: 115366
• Peso molecular: 419.9
• Beilstein: 9967887
• Reaxy-Rn: 9967887

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 30 mg/mL (199.7 mM)
• Rotación específica [α]: 56° (C=1,MeOH)
• Punto de fusión (°C): 174-176°C

Referencias

1. Qiu Wang, Mengchi Sun, Dan Li, Chang Li, Cong Luo, Zhaomeng Wang, Wenjuan Zhang, Zimeng Yang, Yao Feng, Shuang Wang, Zhonggui He, Haotian Zhang, Qiming Kan, Wei Sun, Jin Sun.  (2020)  Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer.  Theranostics,      [PMID:32373230] [10.7150/thno.42633]

2. Jia Zou, Yang Chen, Maggie Pui Man Hoi, Jun Li, Tao Wang, Ying Zhang, Yu Feng, Jianli Gao, Simon Ming Yuen Lee, Guozhen Cui.  (2018)  Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza).  Evidence-based Complementary and Alternative Medicine,      [PMID:29849736] [10.1155/2018/9387568]

3. Jinjing Zhang, Ji Zhu, Bingwei Liu, Wencan Liu, Jiawei Li, Sungjoon Lim, Geunchang Choi, Xu Wu, Yiming Zhu, Yan Peng.  (2025)  Polarization-Induced Multimode Terahertz Metamaterial for High-Sensitivity and Label-free Drug Monitoring.  ANALYTICAL CHEMISTRY,      [PMID:41039830] [10.1021/acs.analchem.5c04376]