Clopidogrel thiolactone - 10mM in DMSO , CAS No.1147350-75-1

CAS: 1147350-75-1 Cat. No.: C656360 Peso molecular: 337.82 PubChem CID: 56848893

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Clopidogrel thiolactone is an active metabolites containing thiols resulting from thionolactone transformation of clopidogrel . Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent

In Vivo

Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) has good biological availability and pharmacokinetic parameters . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley male rats Dosage: 8 μm/kg; orally clopidogrel (24 μm/kg) Administration: Intravenous injection; collected blood at 0 h (before dosing) and 0.083, 0.167, 0.5, 1, 2, 4, 6, 8, 24 h postdose. Result: 1.19 Parameter Clopidogrel C max (μg/L) 6.93 T max (h) 0.583 t 1/2 (h) 2.48 AUC 0-∞ (μg*h/L) 32.2

IC50& Target:P2Y12 Receptor

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Clopidogrel thiolactone is an active metabolites containing thiols resulting from thionolactone transformation of clopidogrel ( HY-15283 ). Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3C(=CC(=O)S3)C2
• PubChem CID: 56848893
• Peso molecular: 337.82