(±)-Sal sódica de cloprostenol - ≥97% , CAS No.55028-72-3

CAS: 55028-72-3 Cat. No.: C287812 Peso molecular: 446.9 Número EC: 259-439-3 PubChem CID: 17756794

GRADE & PURITY ≥97%

Synonyms

(+/-)-SODIUM (Z)-7-((1R*,2R*,3R*,5S*)-2-((E)-(3R*)-4-(M-CHLOROPHENOXY)-3-HYDROXY-1-BUTENYL)-3,5-DIHYDROXYCYCLOPENTYL)-5-HEPTENOATE | Sodium, Cloprostenol | D-Cloprostenol sodium | Estrumate | Sodium(Z)-7-((1R,2R,3R,5S)-2-((R,E)-4-(3-chlorophenoxy)-3-hydro

Storage

Conservar a -20°C,Desecado

Shipped In

Hielera + almohadillas de hielo

Descripción general

Descripción del producto:

El cloprostenol es un análogo sintético de la prostaglandina F2α (PGF). El cloprostenol contribuye a la inducción del estro en animales y tiene actividad uterotónica. El cloprostenol induce el aborto en animales.

Aplicación del producto:

el (+/-)-Cloprostenol sal sódica hidrato se ha utilizado en el estudio de su influencia en la sincronización del estro y el desarrollo uterino en ratones.

Specifications

Sinónimos

(+/-)-SODIUM (Z)-7-((1R*, 2R*, 3R*, 5S*)-2-((E)-(3R*)-4-(M-CHLOROPHENOXY)-3-HYDROXY-1-BUTENYL)-3, 5-DIHYDROXYCYCLOPENTYL)-5-HEPTENOATE | Sodium, Cloprostenol | D-Cloprostenol sodium | Estrumate | Sodium(Z)-7-((1R, 2R, 3R, 5S)-2-((R, E)-4-(3-chlorophenoxy)-3-hydro

Especificaciones y pureza

≥97%

Mecanismos bioquímicos y fisiológicos

Análogo hidrosoluble de la prostaglandina F2α(PGF2α); actúa como un potente agonista del receptor FP (EC50= 0, 84 nM). Inhibe potentemente la diferenciación de las células precursoras de adipocitos. Cloprostenol es un potente agonista del receptor prostano

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C, Desecado

Enviado en

Hielera + almohadillas de hielo

Pureza

≥97%

Nombres e identificadores

• Sonrisas canónicas: C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)[O-])O.[Na+]
• IUPAC Name: sodium;(Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate
• InChIKey: IFEJLMHZNQJGQU-KXXGZHCCSA-M
• INCHI: 1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16-,18-,19-,20+,21-;/m1./s1
• Isómeros SMILES: C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)C/C=C\CCCC(=O)[O-])O.[Na+]
• PubChem CID: 17756794
• Peso molecular: 446.9

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Prostaglandins and related compounds
• Alternative Parents: Long-chain fatty acids Phenoxy compounds Phenol ethers Alkyl aryl ethers Chlorobenzenes Hydroxy fatty acids Unsaturated fatty acids Cyclopentanols Aryl chlorides Cyclic alcohols and derivatives Carboxylic acid salts Organic metal halides Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Carbonyl compounds Hydrocarbon derivatives Organic sodium salts Organic zwitterions Organochlorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Prostaglandin skeleton - Long-chain fatty acid - Phenoxy compound - Phenol ether - Alkyl aryl ether - Halobenzene - Hydroxy fatty acid - Chlorobenzene - Cyclopentanol - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Fatty acid - Benzenoid - Unsaturated fatty acid - Cyclic alcohol - Secondary alcohol - Carboxylic acid salt - Organic metal halide - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic alkali metal salt - Ether - Carboxylic acid - Alcohol - Organohalogen compound - Organochloride - Organooxygen compound - Organic zwitterion - Organic salt - Carbonyl group - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

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KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)

Discover Target: KPNB1

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Objetivos asociados (no humanos)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

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Cruzipain (33337 Activities)

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Plasmodium falciparum (966862 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:water, Max Conc. mg/mL: 8.94, Max Conc. mM: 20
• Sensibilidad: Moisture sensitive.
• Peso molecular: 446.900 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 446.147 Da
• Monoisotopic Mass: 446.147 Da
• Topological Polar Surface Area: 110.000 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 558.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

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