Complement C5 from Human Plasma, CAS No.80295-53-0

CAS: 80295-53-0 Cat. No.: np001101 Peso molecular: 190,000 Da (2 chains)

GRADE & PURITY BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Accession #

P01031

Descripción general

Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.

Complement component C5 is processed by convertase enzymes in a cascade modulated in a unique way. The multi-subunit catalytic complex initially shows little activity against C5, but instead cleaves C3. A C3 cleavage product C3b covalently attaches to the complex and shifts its specificity to C5 by a factor of 1000.

Purity: >=95% by SDS-PAGE.

Reacts to C5 antisera on Western Blot

Not tested for biological activity.

Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests. 

Specifications

Product Name

Complement C5 from Human Plasma, CAS No.80295-53-0

Sinónimos

Complement component C5 | C5D | C5a | C5b | ECLZB | CPAMD4

Grado

BioReagent, Native, PBS Only

Especificaciones y pureza

BioReagent, Native, PBS Only, ≥95%(SDS-PAGE), Protein concentration: See COA

Mecanismos bioquímicos y fisiológicos

Precursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Activated

Número de adhesión

P01031

Peso molecular previsto

190 kDa

CAS

80295-53-0

Tipo de molécula

Protein

Almacenamiento y envío

Forma

Frozen liquid in PBS, pH 7.4

Concentración

Protein concentration: See COA

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ long term (>1 year). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.