Crocetin disodium - 10mM in Water , CAS No.591230-99-8

CAS: 591230-99-8 Cat. No.: C656838 Peso molecular: 372.37 PubChem CID: 10287099

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

In Vitro

Crocetin (Transcrocetin, trans-Crocetin) disodium, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Crocetin disodium at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NMDA Receptor

Specifications

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

Condiciones de almacenamiento de almacenamiento

Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Nombres e identificadores

• Isómeros SMILES: C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)[O-])/C)/C)/C=C/C=C(/C(=O)[O-])\C.[Na+].[Na+]
• PubChem CID: 10287099
• Peso molecular: 372.37