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Crolibulin (EPC2407) - Moligand™,≥98% , Tubulin inhibitor, CAS No.1000852-17-4, Tubulin inhibitor

CAS: 1000852-17-4 Cat. No.: C647301 Peso molecular: 417.26 PubChem CID: 23649181
COA
Crolibulin - ≥98% CAS No(1000852-17-4) by Aladdin Scientific
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
(R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile | EPC2407 | EPC-2407 | Q252344 | D09882 | 1000852-17-4 | AT-20GF | JXONINOYTKKXQQ-CQSZACIVSA-N | BG0 | CROLIBULIN [WHO-DD] | UNII-9ENT43KY91 | Q27272449 | CROLIBULIN [INN] | EX-
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
C647301-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
23,90US$
5mg
C647301-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
82,90US$
25mg
C647301-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
289,90US$
100mg
C647301-100mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
899,90US$
Enter a quantity for the sizes you want to add.
Bulk / Custom
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Descripción general Specifications Propiedades del producto Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas
🧪

Why this grade

Moligand™,≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity

Specifications

Sinónimos
(R)-2, 7, 8-triamino-4-(3-bromo-4, 5-dimethoxyphenyl)-4H-chromene-3-carbonitrile | EPC2407 | EPC-2407 | Q252344 | D09882 | 1000852-17-4 | AT-20GF | JXONINOYTKKXQQ-CQSZACIVSA-N | BG0 | CROLIBULIN [WHO-DD] | UNII-9ENT43KY91 | Q27272449 | CROLIBULIN [INN] | EX-
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Tubulin inhibitor
Pureza
≥98%
Propiedades del producto
ALogP2.6
Nombres e identificadores
Sonrisas canónicasCOC1=C(C(=CC(=C1)C2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
IUPAC Name(4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
InChIKeyJXONINOYTKKXQQ-CQSZACIVSA-N
INCHI1S/C18H17BrN4O3/c1-24-13-6-8(5-11(19)17(13)25-2)14-9-3-4-12(21)15(22)16(9)26-18(23)10(14)7-20/h3-6,14H,21-23H2,1-2H3/t14-/m1/s1
Isómeros SMILES COC1=C(C(=CC(=C1)[C@@H]2C3=C(C(=C(C=C3)N)N)OC(=C2C#N)N)Br)OC
PubChem CID 23649181
Peso molecular 417.26

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
ClaseNeoflavonoids
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentNeoflavonoids
Alternative Parents Dimethoxybenzenes  1-benzopyrans  Phenoxy compounds  Anisoles  Bromobenzenes  Alkyl aryl ethers  Aryl bromides  Ketene acetals  Oxacyclic compounds  Nitriles  Primary amines  Organobromides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Neoflavonoid skeleton - Benzopyran - 1-benzopyran - O-dimethoxybenzene - Dimethoxybenzene - Anisole - Phenoxy compound - Phenol ether - Methoxybenzene - Alkyl aryl ether - Bromobenzene - Halobenzene - Benzenoid - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Ketene acetal or derivatives - Organoheterocyclic compound - Oxacycle - Nitrile - Carbonitrile - Ether - Primary amine - Organic nitrogen compound - Cyanide - Amine - Organic oxygen compound - Organohalogen compound - Organobromide - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as neoflavonoids. These are compounds with a structure based on the 4-phenylchromene backbone.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MKN-45 (2102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SolubilidadDMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming)
Peso molecular417.300 g/mol
XLogP32.600
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass416.048 Da
Monoisotopic Mass416.048 Da
Topological Polar Surface Area130.000 Ų
Heavy Atom Count26
Formal Charge0
Complexity606.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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