Cyclotraxin B, CAS No.1203586-72-4

CAS: 1203586-72-4 Cat. No.: C288514 Peso molecular: 1200.36 PubChem CID: 90489002

GRADE & PURITY ≥98%

Descripción general

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50  of  0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects。

Specifications

Product Name

Cyclotraxin B, CAS No.1203586-72-4

Sinónimos

S-1203586-72-4 | Cyclotraxin B acetate | (3S, 6R, 11R, 17S, 20S, 23S, 26S, 32S, 35S)-6-amino-20-(4-aminobutyl)-3-(2-amino-2-oxoethyl)-17-(2-carboxyethyl)-23-[(1R)-1-hydroxyethyl]-26-[(4-hydroxyphenyl)methyl]-32-(2-methylsulfanylethyl)-2, 5, 13, 16, 19, 22, 25, 28, 31, 34-

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50= 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic pr

Secuencia

CNPMGYTKEGC(Modifications: Disulfide bridge between 1 - 11)

Tipo de acción

INHIBITOR

CAS

1203586-72-4

Tipo de molécula

Small molecule

Almacenamiento y envío

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Argon charged

Enviado en

Ice chest + Ice pads