D-Ala-D-Ala - ≥99% , CAS No.923-16-0

CAS: 923-16-0 Cat. No.: A101620 Peso molecular: 160.17

GRADE & PURITY ≥99%

Synonyms

2-[[(2R)-2-aminopropanoyl]amino]propanoic acid | Z829938994 | HY-N6864 | D-alanyl-D-alanine | DTXSID601016947 | H-D-Ala-D-Ala-OH | Epitope ID:141113 | SCHEMBL476353 | BRN 1363429 | CHEBI:16576 | BDBM50022571 | (D-Ala)2 | (R)-2-((R)-2-Aminopropanamido)prop

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

D-Ala-D-Ala is a biologically active peptide used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplanin, ristocetin, and vancomycin.
A biologically active peptide used for affinity chromatography and binding mechanism studies.

Specifications

Sinónimos

2-[[(2R)-2-aminopropanoyl]amino]propanoic acid | Z829938994 | HY-N6864 | D-alanyl-D-alanine | DTXSID601016947 | H-D-Ala-D-Ala-OH | Epitope ID:141113 | SCHEMBL476353 | BRN 1363429 | CHEBI:16576 | BDBM50022571 | (D-Ala)2 | (R)-2-((R)-2-Aminopropanamido)prop

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

It is found in the stem termini of peptidoglycan side-chain pentapeptide found in the cell walls of gram positive bacteria. The D-ala-d-ala stem termini is the site of interaction of glycopeptide antibiotics such as vancomycin and teicoplanin. D-ala-D-ala

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488195548
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488195548
• Sonrisas canónicas: CC(C(=O)NC(C)C(=O)O)N
• IUPAC Name: (2R)-2-[[(2R)-2-aminopropanoyl]amino]propanoic acid
• InChIKey: DEFJQIDDEAULHB-QWWZWVQMSA-N
• INCHI: 1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1
• Isómeros SMILES: C[C@H](C(=O)N[C@H](C)C(=O)O)N
• WGK Alemania: 3
• Peso molecular: 160.17
• Reaxy-Rn: 1724811
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724811&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: N-acyl-alpha amino acids Alpha amino acid amides Alanine and derivatives Secondary carboxylic acid amides Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alpha-dipeptide - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Alanine or derivatives - Alpha-amino acid or derivatives - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Primary aliphatic amine - Organic nitrogen compound - Carbonyl group - Primary amine - Organic oxygen compound - Hydrocarbon derivative - Amine - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: dipeptide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)

Discover Target: SLC15A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (21 Activities)

Discover Target: murF

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 160.170 g/mol
• XLogP3: -3.300
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 160.085 Da
• Monoisotopic Mass: 160.085 Da
• Topological Polar Surface Area: 92.400 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 169.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Arabi Maryam, Ostovan Abbas, Wang Yunqing, Mei Rongchao, Fu Longwen, Li Jinhua, Wang Xiaoyan, Chen Lingxin.  (2022)  Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.  Nature Communications,  13  (1): (1-14).  [PMID:36180485] [10.1038/s41467-022-33448-w]

2. Xinglong Yang, Yan Dang, Jinli Lou, Huawu Shao, Xingyu Jiang.  (2018)  D-alanyl-D-alanine-Modified Gold Nanoparticles Form a Broad-Spectrum Sensor for Bacteria.  Theranostics,      [PMID:29507633] [10.7150/thno.22540]

3. Lei Dai, Yijiao Xue, Sihan Tian, Ping He, Pan Xie, Zhu Long, Guiqiang Fei, Zhirong Chen.  (2024)  Paper substrate designed with TEMPO-oxidized cellulose nanofibers/cationic guar gum hydrogel and its application in a colorimetric biosensor for rapid bacteria detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38944090] [10.1016/j.ijbiomac.2024.133497]