D-Cl-amidine hydrochloride - ≥99% , CAS No.D659324

CAS: D659324 Cat. No.: D659324 Peso molecular: 347.24

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

Appearance:Solid

In Vitro:D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells. D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis. MCE has not independently conf

In Vivo:D-Cl-amidine, administered by iv at a dose of 2.5mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip

Biological Activity:D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

Specifications

Especificaciones y pureza

≥99%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

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Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

• Peso molecular: 347.24

Propiedades químicas y físicas

• Solubilidad: DMSO : 80 mg/mL (230.39 mM; ultrasonic and warming and heat to 60°C) H2O : 16.67 mg/mL (48.01 mM; ultrasonic and warming and heat to 60°C)