GRADE & PURITY Moligand™, ≥99%

Synonyms

CHEBI:137124 | sphinganine (d17:0), D-erythro-sphinganine (C17 base), powder | 1,3-Heptadecanediol, 2-amino-, (2S,3R)- | Sphinganine-C17 | AKOS040755258 | heptadecasphinganine | SCHEMBL16455713 | D-erythro-sphinganine (C17 base) | LMSP01040003 | (2S,3R)-2

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.
Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for the in-situ estimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.

Specifications

Sinónimos

CHEBI:137124 | sphinganine (d17:0), D-erythro-sphinganine (C17 base), powder | 1, 3-Heptadecanediol, 2-amino-, (2S, 3R)- | Sphinganine-C17 | AKOS040755258 | heptadecasphinganine | SCHEMBL16455713 | D-erythro-sphinganine (C17 base) | LMSP01040003 | (2S, 3R)-2

Especificaciones y pureza

Moligand™, ≥99%

Mecanismos bioquímicos y fisiológicos

Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway.It acts as a precursor for ceramide.SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. I

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCCCCCCCCCCCCCC(C(CO)N)O
• IUPAC Name: (2S,3R)-2-aminoheptadecane-1,3-diol
• InChIKey: KFQUQCFJDMSIJF-DLBZAZTESA-N
• INCHI: 1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1
• Isómeros SMILES: CCCCCCCCCCCCCC[C@H]([C@H](CO)N)O
• Peso molecular: 287.481
• Reaxy-Rn: 38397694
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38397694&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Clase Organonitrogen compounds
      • Subclass Amines
        • Level5 Alkanolamines
          • Level6 1,2-aminoalcohols

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Clase: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines
• Direct Parent: 1,2-aminoalcohols
• Alternative Parents: Secondary alcohols Primary alcohols Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Secondary alcohol - 1,2-aminoalcohol - Organic oxygen compound - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Primary aliphatic amine - Alcohol - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
• External Descriptors: Sphingoid base homologs and variants

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Candida albicans (78123 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 287.500 g/mol
• XLogP3: 5.300
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 15
• Exact Mass: 287.282 Da
• Monoisotopic Mass: 287.282 Da
• Topological Polar Surface Area: 66.500 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1