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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
(D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation.
| Sonrisas canónicas | CC(C)CC(C(=O)O)NC(=O)C(CC1=CN(C=N1)CC2=CC=CC=C2)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CO)NC(=O)C(CC4=CNC5=CC=CC=C54)NC(=O)C(CC6=CN=CN6)NC(=O)C7CCC(=O)N7 |
|---|---|
| IUPAC Name | (2S)-2-[[(2R)-3-(1-benzylimidazol-4-yl)-2-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-methylpentanoic acid |
| InChIKey | PQXRKSVPVKKLGS-NBJPEPGNSA-N |
| INCHI | 1S/C53H62N12O11/c1-30(2)18-44(53(75)76)63-51(73)43(22-35-26-65(29-57-35)25-32-8-4-3-5-9-32)62-48(70)40(19-31-12-14-36(67)15-13-31)59-52(74)45(27-66)64-49(71)41(20-33-23-55-38-11-7-6-10-37(33)38)60-50(72)42(21-34-24-54-28-56-34)61-47(69)39-16-17-46(68)58-39/h3-15,23-24,26,28-30,39-45,55,66-67H,16-22,25,27H2,1-2H3,(H,54,56)(H,58,68)(H,59,74)(H,60,72)(H,61,69)(H,62,70)(H,63,73)(H,64,71)(H,75,76)/t39-,40-,41-,42-,43+,44-,45-/m0/s1 |
| PubChem CID | 131698109 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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