GRADE & PURITY Moligand™, ≥99%

Synonyms

d-leu42 | D-Leucine, ReagentPlus(R), 99% | (2R)-2-azaniumyl-4-methylpentanoate | H-D-Leu-OH | EINECS 206-327-7 | NCGC00013565-03 | DB01746 | Z850973972 | (R)-Leucine | AKOS015841823 | DLE | NSC 77687 | D-Leu | D-Leuzin | BDBM50463213 | NCGC00163335-02 | B

Storage

Room temperature

Shipped In

Normal

Specifications

Sinónimos

d-leu42 | D-Leucine, ReagentPlus(R), 99% | (2R)-2-azaniumyl-4-methylpentanoate | H-D-Leu-OH | EINECS 206-327-7 | NCGC00013565-03 | DB01746 | Z850973972 | (R)-Leucine | AKOS015841823 | DLE | NSC 77687 | D-Leu | D-Leuzin | BDBM50463213 | NCGC00163335-02 | B

Especificaciones y pureza

Moligand™, ≥99%

Condiciones de almacenamiento de almacenamiento

Room temperature

Enviado en

Normal

Grado

Moligand™

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488189745
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488189745
• Sonrisas canónicas: CC(C)CC(C(=O)O)N
• IUPAC Name: (2R)-2-amino-4-methylpentanoic acid
• InChIKey: ROHFNLRQFUQHCH-RXMQYKEDSA-N
• INCHI: 1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m1/s1
• Isómeros SMILES: CC(C)C[C@H](C(=O)O)N
• WGK Alemania: 3
• RTECS: OH2840000
• Peso molecular: 131.17
• Beilstein: 1721721
• Reaxy-Rn: 636005
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=636005&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Leucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Leucine and derivatives
• Alternative Parents: D-alpha-amino acids Methyl-branched fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Leucine or derivatives - Alpha-amino acid - D-alpha-amino acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acid - Fatty acyl - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Other amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Discover Target: SLC7A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Rotación específica [α]: -15 ° (C=4, 6mol/L HCl)
• Punto de fusión (°C): 300°C
• Peso molecular: 131.170 g/mol
• XLogP3: -1.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.095 Da
• Monoisotopic Mass: 131.095 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 101.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang.  (2023)  Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning.  Advanced Science,  11  (9): (2307173).  [PMID:38126652] [10.1002/advs.202307173]

2. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,      [PMID:38072636] [10.1002/advs.202308362]

3. Weijie Fu, Kai Zhang, Xiaohua Zhang, Guorong Fan, Zongde Wang, Shangxing Chen, Yangping Wen, Peng Wang.  (2022)  Synthesis of transition metal sulfide functionalized hierarchically porous carbons and their application as colorimetric-electrochemical dual-mode nanozyme sensing platform for dopamine.  ELECTROCHIMICA ACTA,      [PMID:] [10.1016/j.electacta.2022.141535]

4. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,      [PMID:35272154] [10.1016/j.talanta.2022.123363]

5. Kai Zhang, Zhonghui Zhuo, Guorong Fan, Zongde Wang, Shangxing Chen, Lulu Xu, Yangping Wen, Peng Wang.  (2021)  Nano-ZnS decorated hierarchically porous carbon electrocatalyst with multiple enzyme-like activities as a nanozyme sensing platform for simultaneous detection of dopamine, uric acid, guanine, and adenine.  Nanoscale,  13  (47): (20078-20090).  [PMID:34846060] [10.1039/D1NR06017A]

6. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]

7. Xuan Kuang, Yu Ma, Hao Su, Jine Zhang, Yu-Bin Dong, Bo Tang.  (2014)  High-Performance Liquid Chromatographic Enantioseparation of Racemic Drugs Based on Homochiral Metal–Organic Framework.  ANALYTICAL CHEMISTRY,      [PMID:24380495] [10.1021/ac403674p]

8. Qian Du, Xiaoyu Zhao, Xiping Mei, Yaqin Zhao, Chuan Dong, Junfen Li.  (2024)  A sensitive sensor based on carbon dots for the determination of Fe3+ and ascorbic acid in foods.  Analytical Methods,  16  (6): (939-949).  [PMID:38259231] [10.1039/D3AY02133E]

9. Hui Liu, Huiting Xu, Zhaofeng Song, Zhengwen Li, Saiwei Zhang, Yili Zhang, Jixiang Wang, Xiaoyong Qian.  (2025)  Effects of alkaline pretreatment on the distribution of amino acid enantiomers and their biofunctions during the anaerobic digestion of waste activated sludge.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.159334]

10. Chong Liu, Xiaoxue Han, Qing Zhang, Zhuojia Shi, Yuqing Zhang, Yu Chen.  (2024)  Green low-melting mixture solvents/ionic liquids-based carbon materials and lithium-ion batteries recycling leachate unexpectedly cause water pollution from dissolved organic matter.  JOURNAL OF THE INDIAN CHEMICAL SOCIETY,      [PMID:] [10.1016/j.jics.2024.101458]

11. Lilan Tan, Wenrong Cai, Fangqin Wang, Junyao Li, Datong Wu, Yong Kong.  (2024)  Postsynthetic Modification Strategy for Constructing Electrochemiluminescence-Active Chiral Covalent Organic Frameworks Performing Efficient Enantioselective Sensing.  ANALYTICAL CHEMISTRY,      [PMID:38394220] [10.1021/acs.analchem.3c05887]

12. Luzheng Dong, Jun Wu, Xiashi Zhu.  (2024)  Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers.  CHIRALITY,  36  (4): (e23665).  [PMID:38570326] [10.1002/chir.23665]

13. Chen Qi, Wenke Yang, Fuyan He, Jinshui Yao.  (2020)  The Thermal Properties and Degradability of Chiral Polyester-Imides Based on Several l/d-Amino Acids.  Polymers,  12  (9): (2053).  [PMID:32916788] [10.3390/polym12092053]

14. Mengmeng Ji, Jinwei Li, Liuping Fan, Liang Wang, Shengquan Huang.  (2026)  Combined Effects of Quercetagetin and D-Amino Acids against Pseudomonas aeruginosa: Anti-Quorum Sensing, Antibacterial, and Antibiofilm activities.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2026.108393]

15. Qi Yi, Yi-Qi Sheng, Dong-Qi Han, Xue-Wei Lin, Chi-Kit Siu, Zhong-Ping Yao.  (2026)  Chiral recognition of amino acids by mass spectrometry with the combinations of two different chiral selectors.  Cell Reports Physical Science,      [PMID:] [10.1016/j.xcrp.2026.103144]

16. Simin Zhang, Xiangfeng Chen, Yaping Shi, Xiangyu Zhu, Zongwei Cai.  (2026)  Soft-Chain-Induced Ultrahigh-Resolution Chiral Separation of Amino Acids via Bimetallic Immobilization in MALDI-TIMS-MS.  ANALYTICAL CHEMISTRY,      [PMID:41701523] [10.1021/acs.analchem.5c07869]