DBCO-amine - ≥99.5% , CAS No.1255942-06-3

CAS: 1255942-06-3 Cat. No.: D1372418-GMP Peso molecular: 276.33 Número EC: 836-577-8

GRADE & PURITY ≥99.5%

Synonyms

DBCO-NH2 | -Propanone, 3-amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)- | 1255942-06-3 | ADIBO-amine | Azadibenzocyclooctyne-amine | Dibenzocyclooctyne-amine

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

DBCO-amine GMP is a GMP grade DBCO-amine. DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-amine is a click chemistry reagent, itcontains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Specifications

Sinónimos

DBCO-NH2 | -Propanone, 3-amino-1-(11, 12-didehydrodibenz[b, f]azocin-5(6H)-yl)- | 1255942-06-3 | ADIBO-amine | Azadibenzocyclooctyne-amine | Dibenzocyclooctyne-amine

Especificaciones y pureza

≥99.5%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥99.5%

Nombres e identificadores

• Sonrisas canónicas: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCN
• IUPAC Name: 3-amino-1-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)propan-1-one
• InChIKey: OCCYFTDHSHTFER-UHFFFAOYSA-N
• INCHI: 1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
• Isómeros SMILES: C1C2=CC=CC=C2C#CC3=CC=CC=C3N1C(=O)CCN
• Peso molecular: 276.33
• Reaxy-Rn: 21543048
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21543048&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Beta amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Beta amino acids and derivatives
• Alternative Parents: Benzenoids Tertiary carboxylic acid amides Azacyclic compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Beta amino acid or derivatives - Benzenoid - Tertiary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as beta amino acids and derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Punto de fusión (°C): 86-96° C

Referencias

1. Yueping Li, Shanshan Shan, Ruru Zhang, Chaoping Sun, Xuelan Hu, Jiada Fan, Yi Wang, Ruixue Duan, Mingyuan Gao.  (2024)  Imaging and Downstaging Bladder Cancer with the 177Lu-Labeled Bioorthogonal Nanoprobe.  ACS Nano,      [PMID:38904444] [10.1021/acsnano.4c04303]