Decamethonium Bromide - 10mM in DMSO , Muscle-type nicotinic acetylcholine receptor partial agonist, CAS No.541-22-0, Muscle-type nicotinic acetylcholine receptor partial agonist

CAS: 541-22-0 Cat. No.: D408329 Peso molecular: 418.30 Número EC: 208-772-2

GRADE & PURITY 10mM in DMSO

Synonyms

1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Decamethonium Bromide is a nicotinicAChRpartial agonist andneuromuscularblocking agent.
In vitro

Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥100%

Specifications

Sinónimos

1, 10-Decanediaminium, N1, N1, N1, N10, N10, N10-hexamethyl-, bromide (1:2)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

PARTIAL AGONIST

Mecanismo de acción

Muscle-type nicotinic acetylcholine receptor partial agonist

Nombres e identificadores

• Isómeros SMILES: C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
• WGK Alemania: 3
• RTECS: BP5950000
• Peso molecular: 418.30
• Reaxy-Rn: 3728288
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3728288&ln=

Objetivos asociados (humanos)

ACHE Tclin Acetylcholinesterase (1 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 59 mg/mL (198.82 mM); Ethanol: 2 mg/mL (6.73 mM); Water: Insoluble