Deltonin - 10mM in DMSO , CAS No.55659-75-1

CAS: 55659-75-1 Cat. No.: D654540 Peso molecular: 885.04 PubChem CID: 441884

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis , with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.

In Vitro

Deltonin inhibits ERK1/2 and AKT activation. Deltonin (0.5-8 μM) significantly inhibits the proliferation of several colon cancer cell lines including SW480, SW620, LOVO and C26, with IC 50 s of 1.3, 1.29, 2.11 and 1.22 μM. Deltonin also causes G2-M phase arrest and induces apoptosis in C26 cells. Deltonin (0-5 μM) decreases the phosphorylation of AKT and ERK1/2 levels in MDA‑MB‑231 cells. Deltonin (0.5-8 μM) also dose-dependently inhibits the proliferation, and causes apoptosis with ROS production in MDA‑MB‑231 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:ERK1 ERK2 Akt

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis , has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1
• CAS alternativo: 55659-75-1
• PubChem CID: 441884
• Términos de entrada MeSH: deltonin
• Peso molecular: 885.04