Dexmedetomidine - Moligand™, 10mM in DMSO , Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor, CAS No.113775-47-6, Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor

CAS: 113775-47-6 Cat. No.: D407960 Peso molecular: 200.28 Número EC: 601-281-8
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
(S)-5-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1ml
D407960-1ml
1

190,90US$

277,90US$
Guardar 87,00 US$ (31.31%)
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 22 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
In vitro

Dexmedetomidine has a relatively high ratio of α2/α1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the α2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from α1 receptor activation. The 2-h half-life of dexmedetomidine is nearly 4-fold shorter than that of clonidine, which increases the likelihood that a continuous infusion of dexmedetomidine might be useful for sedation. Dexmedetomidine also has minimum alveolar anesthetic concentration (MAC)-sparing properties, but its use as an anesthetic adjuvant has been complicated by persistent hypotension that has mandated IV fluid administration and vasopressor administration. In addition, its use in large doses is complicated by hypertension from α2 receptor-mediated vascular constriction.

In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Sinónimos
(S)-5-(1-(2, 3-dimethylphenyl)ethyl)-1H-imidazole
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Dexmedetomidine is a sedative medication used by intensive care units and anesthetists.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
AGONIST
Mecanismo de acción
Agonist of α 2A-adrenoceptor;Agonist of α 2B-adrenoceptor;Agonist of α 2C-adrenoceptor
Nombres e identificadores
Isómeros SMILES CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C
Peso molecular 200.28
Reaxy-Rn 5379243
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5379243&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2C Tclin Alpha-2C adrenergic receptor (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA2A Tclin Alpha-2A adrenergic receptor (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADRA1D Tclin Alpha-1D adrenergic receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SolubilidadSolubility (25°C) In vitro DMSO: 33 mg/mL (198.53 mM);    
Punto de fusión (°C)146-149°C
Citations of This Product
Referencias
1. Gao Yang, Kang Kai, Liu Yan-song, Li Na-na, Han Qiu-yuan, Liu Hai-tao, Kong Wei-lan, Zhang Xing, Huang Rui, Yang Zhen-yu, Qi Zhi-dong, Zheng Jun-bo, Li Ming, Wang Hong-liang, Li Jia-yu, Liu Rui-jin, Wang Si-cong, Zhang Wei-hua, Zhao Ming-yan, Yu Kai-jiang.  (2020)  Mechanisms of Renal-Splenic Axis Involvement in Acute Kidney Injury Mediated by the α7nAChR-NF-κB Signaling Pathway.  INFLAMMATION,  44  (2): (746-757).  [PMID:33141376] [10.1007/s10753-020-01374-y]
2. Wang Huikang, Cao Shiya, Pan Di, Faisal Ayub Kiani, Li Hao, Nan Sha, Lin Xuan, Mahmoud M. Abouelfetouh, Zulfiqar Ahmed, Ding Mingxing, Ding Yi.  (2025)  Elucidation of Dexmedetomidine-Induced Analgesic Tolerance Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and NR2B Expression via the Spinal SGK1/NF-κB Signalling Pathway.  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,  29  (6): (e70372).  [PMID:40099662] [10.1111/jcmm.70372]
3. Xufeng Sun, Danlan Fang, Xiaoyu Zhang, Hongjing Zhu, Yingying Sun, Guantong Liu, Bin Sun, Jun Lu, Shoujun Zhu.  (2025)  Engineering Near-Infrared-II Nanoprobes Reveal Dexmedetomidine Potentiating Brain Waste Clearance in Healthy and Sleep-Restricted Mice.  ACS Nano,      [PMID:41004722] [10.1021/acsnano.5c10519]
4. Chenglong Li, Shuhao Xu, Xin Li, Huaiyu Su, Can Qian, Yingying Hou, Sanjun Shi.  (2025)  A Transformable Nanoplatform Precisely Positions Fibroblast-Like Synoviocytes via FAP-α for Improved Rheumatoid Arthritis Therapy.  Advanced Healthcare Materials,      [PMID:40931560] [10.1002/adhm.202503277]
5. Yimei Yang, Jing Xie, Junsu Wang, Hongyu Tu, Ping Lu, Kun Yu, Fei Lu, Guangqian Lan, Ruiqi Xie, Rong Yin, Enling Hu, Wentao Lin, Xianglin Lin.  (2025)  Polyphenol-functionalized silk fibroin incorporates self-assembled drug delivery platforms for oral ulcers treatment by robust wet adhesion and sustained drug release.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40945820] [10.1016/j.ijbiomac.2025.147592]
6. Zhuohui Luo, Zaibin Xu, Kongyan Wang, Huiyu Hu, Jiawen Huang.  (2025)  Citri Sarcodactylis Fructus Alleviates LPS‐Induced Acute Lung Injury by Inhibiting Inflammation and Inflammasome Activation.  Food Science & Nutrition,  13  (9): (e70881).  [PMID:40901654] [10.1002/fsn3.70881]
7. XiaoRong Meng, Dandan Meng, Chenhui Xiang, Lingling Pu, Xiaofei Yin, Jing Yang.  (2025)  Apelin-13 treats postmenopausal osteoporosis by reducing mitochondrial oxidative phosphorylation and modulating the OPG/RANK/RANKL/IGF-1 pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:41043277] [10.1016/j.bbrc.2025.152738]
8. Zengjun Xie, Zhihui He, Zhen Yuan, Miao Wang, Feifan Zhou.  (2024)  The Regulation of Cerebral Lymphatic Drainage in the Transverse Sinus Region of the Mouse Brain.  Journal of Biophotonics,      [PMID:39289863] [10.1002/jbio.202400250]
9. Yaqing Kang, Xiaoqing Han, Shijie Zhou, Xingbo Wang, Yanjing Wang, Panpan Song, Xiaochen Su, Mengmeng Qin, Dongyang Qian, Huan Meng, Jiao Yan, Fang Pu, Haiyuan Zhang.  (2025)  Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment.  ADVANCED MATERIALS,      [PMID:41041946] [10.1002/adma.202508072]
10. Hui Ma, Jiancheng Zhao, Wenbo Dong, Gang Wei, Pan Zhou, Xingshun Cong, Kefeng Wu, Yingxiong Wang, Jing Liao, Qi Zhao.  (2025)  High-resolution pure shift NMR spectroscopy for fast structural analysis of complex drug compounds with overlapping multiplets.  JOURNAL OF MOLECULAR STRUCTURE,      [PMID:] [10.1016/j.molstruc.2025.142492]
11. Shixin Lu, Zhaopeng Cai, Yuheng Lu, Youchen Tang, Jiapeng Song, Jiajun Huang, Ziying Cheng, Dingcai Wu, Peng Wang.  (2025)  A universal strategy for growing multifunctional hydrogel coatings on diverse polymers via Fenton reaction.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163936]
12. Lan Tang, Xin Zhang, Ye Huang, Depeng Kong, Yiwen Yan, Zhimin Ou, Mulan Zhu, Yi Li, Jianwei Wang.  (2025)  Study on dexamethasone-fast dissolving oral film based on pullulan-vitamin E succinic acid.  Journal of Radiation Research and Applied Sciences,      [PMID:] [10.1016/j.jrras.2025.101653]
13. Liang Shan, Liu Shiwei, Long Zhihe, Li Xiaojiao, Han Qian, Wei Xianhao, Xing Lili, Xue Xinyu, Chen Meihua.  (2025)  A self-powered hydration-monitoring and drug-delivery skin patch for closed-loop treatment of atopic dermatitis.  Microsystems & Nanoengineering,  11  (1): (1-14).  [PMID:40825931] [10.1038/s41378-025-01000-7]
14. Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang.  (2025)  Constitutive Androstane Receptor in Macrophages Regulates Toll-Like Receptor 4-Mediated Innate Immune Responses Against Endotoxemic Liver Injury.  Advanced Science,      [PMID:40820881] [10.1002/advs.202506725]
15. Yu Li, Pei Xie, Ruixin Gong, Junlong Chen, Yaxue Liu, Zongning Yin.  (2025)  Treating rheumatoid arthritis using fibroblast-activated protein-α-responsive micelles through a cascade control program.  Journal of Materials Chemistry B,      [PMID:41114432] [10.1039/D5TB01441G]
16. Qianqian Wang, Juan Du, Enling Ye, Zhongyan Bao, Minjie Zhao, Jing Wang, Fengqin Feng, Weihong Min, Hong Yang.  (2025)  Wheat peptides improved sarcopenia by enhancing muscle protein synthesis in mice and zebrafish.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107717]
17. Sifang Zhao, Fengjiao Chen, Mengxin Ban, Jian Zhou, Kerong Wu, Tengbo Yu, Bowen Chen, Lingling Zhao, Ziyu Liu.  (2025)  Phenylboronic Acid-Modified and ROS-Responsive Polymeric Nanoparticles for Targeted Anticancer Drug Delivery.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.5c03593]
18. Pengchao Zhao, Zhishen Zhang, Dianhao Gong, Hongzhen Luo, Huiying Yu, Xin Li, Kun Lei, Chunshan Quan, Yun Xue, Lijun Guan.  (2025)  Multifunctional Prussian-Blue-Based Nanocomposite Hydrogel for Infected Wound Regeneration.  Gels,  11  (11): (895).  [PMID:41294580] [10.3390/gels11110895]
19. Min-Jie Shi, Jiang-Zheng Liu, Wei-Hua Yu, Rui Liu, Lu-Yao Li, Meng Cao, Yun-Ze Tian, Xiao-Di Zhang, Hao Wu, Jian-Zhong Li, Chun-Xu Hai, Wen-Li Li, Jia Li, De-Qin Kong.  (2025)  Repurposing the anesthetic dexmedetomidine: a novel antidote for sulfur mustard analog-induced acute lung injury via multi-mechanism modulation.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:41421231] [10.1016/j.intimp.2025.116069]
20. Gongshuai Song, Tian Zhao, Yingcong Yang, Yangcheng Ge, Wei Tang, Taijiao Xiang, Danli Wang, Tinglan Yuan, Ling Li, Yong Cheng, Mengna Zhang, Jinyan Gong.  (2026)  Promoting the formation of β-lactoglobulin amyloid fibrils induced by cold plasma treatment: self-assembly mechanism, emulsifying properties, and stability.  FOOD RESEARCH INTERNATIONAL,      [PMID:41763791] [10.1016/j.foodres.2026.118469]
21. Limei Zhu, Rongrong Pan, Rongjiao Sun, Yueqi Jin, Kemin Yang, Xianzhu You, Jiante Li, Jiangqian Kong, Ying Tan, Jiajia Dong, Wanle Hu.  (2026)  Engineering carboxymethyl chitosan/dialdehyde starch hydrogel as a therapeutic platform for immuno-microbial modulation in ulcerative colitis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41722795] [10.1016/j.ijbiomac.2026.151026]
22. Zuoxi Zhang, Kexin Yin, Bowen Li, Huining He, Yang Bai, Bin Zheng.  (2026)  Hijacking Actin-Pre-Liquid–Liquid Phase Separation Suppresses Malignant Tumor Invasion and Growth.  Journal of the American Chemical Society,      [PMID:] [10.1021/jacs.5c19435]
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