≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Information
Dibucaine HCl Dibucaine HCl (Cinchocaine) is a local anesthetics.
Targets
Sodium channel
In vitro
Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane\'s permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
1.Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi. (2023) Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY, [PMID:37560898][10.1021/acs.analchem.3c02123]
2.Lin Yue, Min Wang, Imran Mahmood Khan, Sobia Niazi, Bin Wang, Xiaoyuan Ma, Zhouping Wang, Wenshui Xia. (2021) Preparation and characterization of chitosan oligosaccharide derivatives containing cinnamyl moieties with enhanced antibacterial activities. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:][10.1016/j.lwt.2021.111663]
3.Feng Jiang, Guoping Wu, Wanrong Li, Jiajia Yang, Junli Yan, Yi Wang, Wenli Yao, Xue Zhou, Zhiyong He, Linjing Wu, Chaoda Xiao, Ting Xiao, Min Zhang, Xiangchun Shen, Ling Tao. (2018) Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:30336203][10.1016/j.ejps.2018.10.012]
4.He Tian-Fu, Wang Lang-Hong, Niu De-bao, Wen Qing-hui, Zeng Xin-An. (2018) Cinnamaldehyde inhibit Escherichia coli associated with membrane disruption and oxidative damage. ARCHIVES OF MICROBIOLOGY, 201 (4):(451-458). [PMID:30293114][10.1007/s00203-018-1572-5]
5.Tian-Fu He, Zhi-Hong Zhang, Xin-An Zeng, Lang-Hong Wang, Charles S. Brennan. (2017) Determination of membrane disruption and genomic DNA binding of cinnamaldehyde to Escherichia coli by use of microbiological and spectroscopic techniques. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, [PMID:29306845][10.1016/j.jphotobiol.2017.11.015]
6.Yi Jun Zhang, Ming Xian Huang, Yu Ping Zhang, Daniel Wayne Armstrong, Zachary S. Breitbach, Jae Jeong Ryoo. (2013) Use of Sulfated Cyclofructan 6 and Sulfated Cyclodextrins for the Chiral Separation of Four Basic Pharmaceuticals by Capillary Electrophoresis. CHIRALITY, 25 (11):(735-742). [PMID:23939835][10.1002/chir.22206]
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