Diclofenac Potassium - 10mM in DMSO , Cyclooxygenase inhibitor, CAS No.15307-81-0, Cyclooxygenase inhibitor

CAS: 15307-81-0 Cat. No.: D409053 Peso molecular: 334.24 Número EC: 630-422-6 PubChem CID: 23667642

GRADE & PURITY 10mM in DMSO

Synonyms

CGP-45840B | potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
In vitro

The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

CGP-45840B | potassium 2-(2-(2, 6-dichlorophenylamino)phenyl)acetate

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Diclofenac potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Mecanismo de acción

Cyclooxygenase inhibitor

Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[K+]
• PubChem CID: 23667642
• Peso molecular: 334.24

Referencias

1. Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao.  (2022)  Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method.  CHROMATOGRAPHIA,  85  (3): (221-231).  [PMID:] [10.1007/s10337-021-04126-8]

2. Zheng-Kang Luo, Hui-Min Qin, Jin-Meng Han, Jin Zhu, Yu-Yu Zeng, Chang-Ping Fan, Shu-Xian Liu, Chao Hao, Jian Zhang, Tao Zhuang.  (2024)  Novel drug-drug co-amorphous systems of olaparib with nonsteroidal anti-inflammatory drugs with improved solubility, physical stability, antitumor activity and pharmacokinetics.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2024.106232]