La dictamnina (Dictamine) tiene la capacidad de ejercer citotoxicidad en células humanas de carcinoma de cérvix, colon y boca; Se ha informado de que un producto vegetal natural tiene actividad antimicrobiana contra bacterias y hongos. Valor IC50: Objetivo: La dicamnina tiene actividad antimicrobiana contra el hongo modelo Saccharomyces cerevisiae, con un valor de concentración inhibitoria mínima (CIM) de 64 microg/ml . Dic indujo la detención del ciclo celular en fase S a baja concentración y la apoptosis celular a alta concentración en la que la pérdida de potencial de membrana mitocondrial (Δψmm) no estuvo implicada. Además, la inhibición de la caspasa-3 utilizando el inhibidor específico, z-DQMD-fmk, no atenuó la apoptosis inducida por Dic, lo que implica que la apoptosis inducida por Dic es independiente de la caspasa-3.

Specifications

Sinónimos

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Pureza

≥98%

Nombres e identificadores

Pubchem Sid	504754247
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504754247
Sonrisas canónicas	COC1=C2C=COC2=NC3=CC=CC=C31
IUPAC Name	4-methoxyfuro[2,3-b]quinoline
InChIKey	WIONIXOBNMDJFJ-UHFFFAOYSA-N
INCHI	1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3
Isómeros SMILES	COC1=C2C=COC2=NC3=CC=CC=C31
Peso molecular	199.21
Reaxy-Rn	176932
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=176932&ln=

Documentation

📋 Safety Data Sheet (SDS)

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Clase Quinolines and derivatives
    - Subclass Furanoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Clase	Quinolines and derivatives
Subclass	Furanoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Furanoquinolines
Alternative Parents	Furopyridines Alkyl aryl ethers Pyridines and derivatives Benzenoids Heteroaromatic compounds Furans Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Furanoquinoline - Furopyridine - Alkyl aryl ether - Pyridine - Benzenoid - Furan - Heteroaromatic compound - Azacycle - Ether - Oxacycle - Hydrocarbon derivative - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as furanoquinolines. These are compounds containing a furan ring fused to a quinoline.
External Descriptors	Alkaloids - Quinoline alkaloids
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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KCNA3 Tclin Voltage-gated potassium channel subunit Kv1.3 (1067 Activities)

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Raji (5516 Activities)

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HepG2 (196354 Activities)

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CAL-27 (814 Activities)

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SCC-9 (213 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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Objetivos asociados (no humanos)

Staphylococcus aureus (210822 Activities)

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Bacillus subtilis (32866 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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Candida albicans (78123 Activities)

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CHO (4503 Activities)

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N1E-115 (121 Activities)

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Tribolium castaneum (596 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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Sitophilus zeamais (188 Activities)

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Mecanismos de acción

Certificados (CoA, COO, BSE/TSE y tabla de análisis)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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3 results found

Lot Number	Certificate Type	Fecha	Articulo
I2118311	Certificate of Analysis	Jul 16, 2024	D303797
I2118314	Certificate of Analysis	Jul 16, 2024	D303797
I2118315	Certificate of Analysis	Jul 16, 2024	D303797

Propiedades químicas y físicas

Solubilidad	DMSO : 50 mg/mL
Peso molecular	199.200 g/mol
XLogP3	2.700
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	199.063 Da
Monoisotopic Mass	199.063 Da
Topological Polar Surface Area	35.300 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	234.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Calculadoras de soluciones

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Dictamnine - ≥98% , CAS No.484-29-7

Why this grade

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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