Pirrocarbonato de dietilo - Moligand™,≥97% , CAS No.1609-47-8

CAS: 1609-47-8 Cat. No.: D137738 Fórmula: C₆H₁₀O₅ Peso molecular: 162.14 Beilstein Registry Number: 637031 Número EC: 216-542-8

GRADE & PURITY Moligand™, ≥97%

Synonyms

DEP | 3,3',5,5'-tetraethylbenzidine | Diethyl ester of pyrocarbonic acid | diethyl pyrocarbonate | InChI=1/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H | Diethylpyrocarbonate | diethyl-pyrocarbonate | carbonic acid, ethoxycarbonyl ethyl ester | CAS-1609-4

Storage

Conservar a 2-8°C,cargado con argón

Shipped In

Hielo húmedo

Descripción general

Se ha demostrado que el pirocarbonato de dietilo inhibe la unión de la rianodina a los canales receptores de rianodina/Ca2+ en el músculo esquelético de forma dependiente de la dosis y del tiempo y aumenta la permeabilidad al Ca2+ de las vesículas SR. Este compuesto podría ser útil para la inactivación específica de nucleasas durante el aislamiento de polinucleótidos no degradados. El pirocarbonato de dietilo también inhibe la acetilhidrolasa PAF (acetilhidrolasa del factor activador de plaquetas), y se ha utilizado como sonda para la topografía del ARNr 5,8S en ribosomas de levadura.
Inhibidor de la unión de la rianodina al canal rianodina/Ca2

Specifications

Sinónimos

DEP | 3,3',5,5'-tetraethylbenzidine | Diethyl ester of pyrocarbonic acid | diethyl pyrocarbonate | InChI=1/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H | Diethylpyrocarbonate | diethyl-pyrocarbonate | carbonic acid, ethoxycarbonyl ethyl ester | CAS-1609-4

Especificaciones y pureza

Moligand™, ≥97%

Mecanismos bioquímicos y fisiológicos

Inactiva la RNasa en solución a aproximadamente el 0,1% (v/v), protegiendo así el ARN contra la degradación.

Condiciones de almacenamiento de almacenamiento

Conservar a 2-8°C,cargado con argón

Enviado en

Hielo húmedo

Grado

Moligand™

Pureza

≥97%

Nombres e identificadores

Pubchem Sid

488179737

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488179737

Sonrisas canónicas

CCOC(=O)OC(=O)OCC

IUPAC Name

ethoxycarbonyl ethyl carbonate

InChIKey

FFYPMLJYZAEMQB-UHFFFAOYSA-N

INCHI

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

Isómeros SMILES

CCOC(=O)OC(=O)OCC

WGK Alemania

3

RTECS

LQ9350000

Peso molecular

162.14

Beilstein

637031

Reaxy-Rn

637031

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=637031&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Organic carbonic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Organic carbonic acids and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Organic carbonic acids and derivatives
• Alternative Parents: Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Carbonic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Descripción: This compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SOAT2 Tchem Acyl coenzyme A:cholesterol acyltransferase 2 (288 Activities)

Discover Target: SOAT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Soat1 Acyl coenzyme A:cholesterol acyltransferase 1 (295 Activities)

Discover Target: Soat1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble in water with hydrolytic decomposition yielding ethanol and CO2., Soluble in chloroform, ethanol (50% w/w), esters, ketones, and hydrocarbons.Slowly soluble in wate
• Sensibilidad: Heat and Moisture sensitive
• Índice de refracción: n20/D 1.398
• Punto de inflamación (°F): 156.2 °F
• Punto de inflamación (°C): 69℃
• Punto de ebullición (°C): 93-94 °C
• Peso molecular: 162.140 g/mol
• XLogP3: 1.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 162.053 Da
• Monoisotopic Mass: 162.053 Da
• Topological Polar Surface Area: 61.800 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 126.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1