Diltiazem HCl - 10mM in DMSO , CAS No.33286-22-5

CAS: 33286-22-5 Cat. No.: D408398 Peso molecular: 450.98 Número EC: 251-443-3

GRADE & PURITY 10mM in DMSO

Synonyms

RG 83606 HCl | (2S,​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2,​3-​dihydro-​2-​(4-​methoxyphenyl)​-1,​5-​benzothiazepin-​4(5H)​-​one,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Diltiazem HCl Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
In vitro

In vivo

Cell Data

cell lines：HCT116, HCT116 p53−/−, EW36, BL2, NTera2D, NTera2D-DNp53, ARN8, NHDF, SKNH-pCMV and SKNSH-DNp53.

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

RG 83606 HCl | (2S, ​3S)​- 3-​(acetyloxy)​-​5-​[2-​(dimethylamino)​ethyl]​-​2, ​3-​dihydro-​2-​(4-​methoxyphenyl)​-1, ​5-​benzothiazepin-​4(5H)​-​one, hydrochloride (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl
• WGK Alemania: 3
• RTECS: DL0310000
• CAS alternativo: 42399-41-7
• Peso molecular: 450.98
• Reaxy-Rn: 6889420
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6889420&ln=

Propiedades químicas y físicas

• Rotación específica [α]: 114 to 122 deg(C=1, H2O)
• Punto de fusión (°C): 210 °C

Referencias

1. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng.  (2022)  Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo.  Frontiers in Pharmacology,      [PMID:36052128] [10.3389/fphar.2022.909168]