Dinoprost - ≥99% , Prostanoid FP receptor agonist, CAS No.38562-01-5, Prostanoid FP receptor agonist

CAS: 38562-01-5 Cat. No.: D136300 Peso molecular: 475.62 Beilstein Registry Number: 4087514 Número EC: 254-002-3 PubChem CID: 5282415

GRADE & PURITY ≥99%

Synonyms

Sal de trometamina de prostaglandina F2 alfa | Solución estéril de prostaglandina F2 alfa | CT6BBQ5A68 | 2-Amino-2-(hidroximetil)propano-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-Dihidroxi-2-((S,E)-3-hidroxioct-1-en-1-il)ciclopentilo)hept-5-enoato | Dinoprost tro

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

Dinoprost Trometamina es un análogo sintético de la prostaglandina F2 alfa natural, que estimula la actividad miometrial, relaja el cuello uterino, inhibe la esteroidogénesis del cuerpo lúteo e induce la luteólisis por acción directa sobre el cuerpo lúteo.

Specifications

Sinónimos

Sal de trometamina de prostaglandina F2 alfa | Solución estéril de prostaglandina F2 alfa | CT6BBQ5A68 | 2-Amino-2-(hidroximetil)propano-1, 3-diol (Z)-7-((1R, 2R, 3R, 5S)-3, 5-Dihidroxi-2-((S, E)-3-hidroxioct-1-en-1-il)ciclopentilo)hept-5-enoato | Dinoprost tro

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Agonista de los receptores de prostaglandina E2y F2α. Prostaglandina natural y potente vasoconstrictor. Induce la hipertrofia de los cardiomiocitos in vitro. Presenta actividad luteolítica.

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Tipo de acción

AGONIST

Mecanismo de acción

Prostanoid FP receptor agonist

Pureza

≥99%

Nombres e identificadores

• Sonrisas canónicas: CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
• IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid
• InChIKey: IYGXEHDCSOYNKY-RZHHZEQLSA-N
• INCHI: 1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1
• Isómeros SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
• WGK Alemania: 3
• RTECS: UK8025000
• PubChem CID: 5282415
• Peso molecular: 475.62
• Beilstein: 4087514

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Clase Fatty Acyls
      • Subclass Eicosanoids

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Clase: Fatty Acyls
• Subclass: Eicosanoids
• Intermediate Tree Nodes: Not available
• Direct Parent: Prostaglandins and related compounds
• Alternative Parents: Long-chain fatty acids Hydroxy fatty acids Unsaturated fatty acids Cyclopentanols Cyclic alcohols and derivatives Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: Prostaglandin skeleton - Long-chain fatty acid - Hydroxy fatty acid - Cyclopentanol - Fatty acid - Unsaturated fatty acid - Cyclic alcohol - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxide - Organic oxygen compound - Alcohol - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as prostaglandins and related compounds. These are unsaturated carboxylic acids consisting of a 20 carbon skeleton that also contains a five member ring, and are based upon the fatty acid arachidonic acid.
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

Discover Target: GBA1

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

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HEK293 (82097 Activities)

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SLC5A7 Tchem High-affinity choline transporter (1462 Activities)

Discover Target: SLC5A7

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ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

Discover Target: ABCC2

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ABCB11 Tchem Bile salt export pump (2311 Activities)

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ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

Discover Target: ABCC3

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LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

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GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

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Objetivos asociados (no humanos)

Cruzipain (33337 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 47.56, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 47.56, Max Conc. mM: 100
• Peso molecular: 475.600 g/mol
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 15
• Exact Mass: 475.315 Da
• Monoisotopic Mass: 475.315 Da
• Topological Polar Surface Area: 185.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 486.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3