Diphemanil Methylsulfate - 10mM in DMSO , Muscarinic acetylcholine receptor M1 antagonist, CAS No.62-97-5, Muscarinic acetylcholine receptor M1 antagonist

CAS: 62-97-5 Cat. No.: D409097 Fórmula: C₂₁H₂₇NO₄OS Peso molecular: 405.51 Número EC: 200-552-4

GRADE & PURITY 10mM in DMSO

Synonyms

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).
In vitro

Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth musclespasmolytic activity.

In vivo

The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-, methyl sulfate (1:1)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR).

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ANTAGONIST

Mecanismo de acción

Muscarinic acetylcholine receptor M1 antagonist

Nombres e identificadores

Isómeros SMILES

C[N+]1(CCC(=C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C.COS(=O)(=O)[O-]

RTECS

TN5075000

Peso molecular

405.51

Reaxy-Rn

3842254

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3842254&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 34 mg/mL (113.92 mM); Ethanol: 28 mg/mL (93.81 mM); Water: Insoluble
• Punto de fusión (°C): 194 °C