Dipyridamole (NSC 515776) - Moligand™, 10mM in DMSO , 3',5'-cyclic phosphodiesterase inhibitor, CAS No.58-32-2, 3',5'-cyclic phosphodiesterase inhibitor

CAS: 58-32-2 Cat. No.: D409128 Peso molecular: 504.63 Beilstein Registry Number: 26(3/4)3840 Número EC: 200-374-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Persantine | Ethanol, 2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Dipyridamole (NSC 515776) Dipyridamole (NSC-515776, Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
In vitro

In vivo

Cell Data

cell lines：Epimastigote form of T. cruzi amastigotes

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Persantine | Ethanol, 2, 2', 2'', 2'''-[(4, 8-di-1-piperidinylpyrimido[5, 4-d]pyrimidine-2, 6-diyl)dinitrilo]tetrakis-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Dipyridamole (NSC-515776, Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

3', 5'-cyclic phosphodiesterase inhibitor

Propiedades del producto

• ALogP: 0.7

Nombres e identificadores

• Isómeros SMILES: C1CCN(CC1)C2=NC(=NC3=C2N=C(N=C3N4CCCCC4)N(CCO)CCO)N(CCO)CCO
• WGK Alemania: 2
• RTECS: KK7450000
• Peso molecular: 504.63
• Beilstein: 26(3/4)3840
• Reaxy-Rn: 68373
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=68373&ln=

Objetivos asociados (humanos)

PRUNE1 Tchem Exopolyphosphatase PRUNE1 (1 Activities)

Discover Target: PRUNE1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC29A1 Tclin Equilibrative nucleoside transporter 1 (4 Activities)

Discover Target: SLC29A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC29A4 Tchem Equilibrative nucleoside transporter 4 (1 Activities)

Discover Target: SLC29A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE11A Tchem Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (1 Activities)

Discover Target: PDE11A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE8A Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (1 Activities)

Discover Target: PDE8A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE10A Tclin cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (1 Activities)

Discover Target: PDE10A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE8B Tclin High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (1 Activities)

Discover Target: PDE8B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE5A Tclin cGMP-specific 3',5'-cyclic phosphodiesterase (2 Activities)

Discover Target: PDE5A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: 100 mg/mL Ethanol: 100 mg/mL
• Punto de fusión (°C): 165-166°C

Referencias

1. Qingquan Zeng, Mengru Bai, Cui Li, Shuanghui Lu, Zhiyuan Ma, Yunchun Zhao, Hui Zhou, Huidi Jiang, Dongli Sun, Caihong Zheng.  (2019)  Multiple Drug Transporters Contribute to the Placental Transfer of Emtricitabine.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,      [PMID:31160284] [10.1128/AAC.00199-19]

2. Jiaying Song, Xingyi Li, Kailibinuer Abuduwaili, Yue Sun, Jiangbo Li, Danying Chen, Zhuofan Chen, Zhipeng Li, Baoxin Huang.  (2025)  Dipyridamole Attenuates Experimental Periodontitis by Regulating M1 Macrophage Polarization via PKA/PKG Pathways.  JOURNAL OF PERIODONTAL RESEARCH,      [PMID:39799459] [10.1111/jre.13378]

3. Mengru Bai, Qian Shen, Yong Wu, Zhiyuan Ma, Yuqing Wang, Mingyang Chen, Dan Liu, Lin Zhou.  (2024)  Evaluation of transport mechanisms of methotrexate in human choriocarcinoma cell lines by LC-MS/MS.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:38823222] [10.1016/j.jpba.2024.116268]

4. Yu Su, Haobo Wen, Ke Hu, Cuiping Wen, Ping Wang, Lulu Zhao, Gang Zou, Wei Jiang, Yaxi Chen, Yunfei Zhao, Qiu Li.  (2026)  An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41866523] [10.1186/s12951-026-04301-9]