DL-Buthionine-(S,R)-sulfoximine hydrochloride - 10mM in DMSO , CAS No.D661656(DMSO)

CAS: D661656(DMSO) Cat. No.: D661656 Peso molecular: 258.77

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis .

IC50& Target:Glutamylcysteine synthetase

In Vitro:Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine. MCE has no

In Vivo:Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tum

Biological Activity:DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis .

Specifications

Especificaciones y pureza

10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Protected from light, Desiccated, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ACTIVATOR

Nombres e identificadores

• Peso molecular: 258.77