DL-Mevalonolactone - 10mM in DMSO , CAS No.674-26-0

CAS: 674-26-0 Cat. No.: D425392 Fórmula: C₆H₁₀O₃ Peso molecular: 130.14 Número EC: 211-615-0

GRADE & PURITY 10mM in DMSO

Synonyms

LMFA07040003 | 1RJ06DC41B | MEVALONOLACTONE, DL- | Mevalonic acid .delta.-lactone | 009D7F12-69C6-4BBF-A66D-12BA84648C72 | AS-65830 | HMS2097E22 | NCGC00179453-01 | .beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone | 2H-PYRAN-2-ONE, TETRAHYDRO-4-HYDROXY-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Product Introduction

Alkaline hydrolysis of mevalonolactone gives mevalonate. Mevalonate is a precursor of farnesyl and geranylgeranyl pyrophosphates. These pyrophosphates are required for protein prenylation. 

Application

(±)-Mevalonolactone is used to:

• study the effect of statin on the prenylation of Ras and Rho GTPases

• analyse the isoprenoid biosynthesis pathways in Listeria monocytogenes

• study the the effects of statins on proliferation and migration of HUVECs (HGF-induced human umbilical vein endothelial cells) 

Specifications

Sinónimos

LMFA07040003 | 1RJ06DC41B | MEVALONOLACTONE, DL- | Mevalonic acid .delta.-lactone | 009D7F12-69C6-4BBF-A66D-12BA84648C72 | AS-65830 | HMS2097E22 | NCGC00179453-01 | .beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone | 2H-PYRAN-2-ONE, TETRAHYDRO-4-HYDROXY-

Especificaciones y pureza

10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

Pubchem Sid

528764174

Sonrisas canónicas

CC1(CCOC(=O)C1)O

IUPAC Name

4-hydroxy-4-methyloxan-2-one

InChIKey

JYVXNLLUYHCIIH-UHFFFAOYSA-N

INCHI

1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3

Isómeros SMILES

CC1(CCOC(=O)C1)O

Peso molecular

130.14

Reaxy-Rn

80960

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=80960&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Lactones
      • Subclass Delta valerolactones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Lactones
• Subclass: Delta valerolactones
• Intermediate Tree Nodes: Not available
• Direct Parent: Delta valerolactones
• Alternative Parents: Oxanes Tertiary alcohols Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Delta_valerolactone - Delta valerolactone - Oxane - Tertiary alcohol - Carboxylic acid ester - Oxacycle - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as delta valerolactones. These are cyclic organic compounds containing an oxan-2- one moiety.
• External Descriptors: Lactones

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Moisture & heat sensitive
• Índice de refracción: 1.48
• Punto de inflamación (°F): 235.4 °F
• Punto de inflamación (°C): 113 °C
• Punto de ebullición (°C): 150 °C/5 mmHg
• Punto de fusión (°C): 28 °C
• Peso molecular: 130.139 g/mol
• XLogP3: -0.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 130.063 Da
• Monoisotopic Mass: 130.063 Da
• Topological Polar Surface Area: 46.500 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 132.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1