Docebenone - 10mM in DMSO , CAS No.80809-81-0

CAS: 80809-81-0 Cat. No.: D655736 Peso molecular: 326.43 Número EC: 635-956-3 PubChem CID: 1967

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

In Vitro

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB 4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca 2+ ] i concentration dependently. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10 -8 -10 -5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10 -8 -10 -5 M. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:5-LO

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC1=C(C(=O)C(=C(C1=O)C)CCCCC#CCCCC#CCO)C
• CAS alternativo: 80809-81-0
• PubChem CID: 1967
• Términos de entrada MeSH: 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone;AA 861;AA-861;AA861
• Peso molecular: 326.43