Donepezil HCl - 10mM in Water , Acetylcholinesterase inhibitor, CAS No.120011-70-3, Acetylcholinesterase inhibitor

CAS: 120011-70-3 Cat. No.: D420883 Peso molecular: 415.96 Número EC: 620-543-2
Disponible para pedir
GRADE & PURITY 10mM in Water
Synonyms
DONEPEZIL HYDROCHLORIDE [JAN] | DONEPEZIL HYDROCHLORIDE [MI] | s2462 | (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one monohydrochloride | CCG-101043 | Tox21_112534_1 | DTXCID8026698 | E 2020 | EN300-269733 | FT-0602354
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Estado
Price
Qty
1ml
D420883-1ml
2

47,90US$

69,90US$
Guardar 22,00 US$ (31.47%)
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Why this grade

10mM in Water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 21 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
A noncompetitive acetylcholinesterase (AChE) inhibitor.

Specifications

Sinónimos
DONEPEZIL HYDROCHLORIDE [JAN] | DONEPEZIL HYDROCHLORIDE [MI] | s2462 | (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-one monohydrochloride | CCG-101043 | Tox21_112534_1 | DTXCID8026698 | E 2020 | EN300-269733 | FT-0602354
Especificaciones y pureza
10mM in Water
Mecanismos bioquímicos y fisiológicos
Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain aga
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Mecanismo de acción
Acetylcholinesterase inhibitor
Nombres e identificadores
Sonrisas canónicasCOC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
IUPAC Name2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
InChIKeyXWAIAVWHZJNZQQ-UHFFFAOYSA-N
INCHI1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
Isómeros SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
WGK Alemania 1
RTECS NK8927885
CAS alternativo 110119-84-1
Peso molecular 415.96
Reaxy-Rn 7062905
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7062905&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClasePiperidines
SubclassBenzylpiperidines
Intermediate Tree Nodes Not available
Direct ParentN-benzylpiperidines
Alternative Parents Indanones  Phenylmethylamines  Benzylamines  Aryl alkyl ketones  Anisoles  Aralkylamines  Alkyl aryl ethers  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents N-benzylpiperidine - Indanone - Indane - Anisole - Benzylamine - Phenylmethylamine - Aryl ketone - Aryl alkyl ketone - Alkyl aryl ether - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Tertiary aliphatic amine - Tertiary amine - Ketone - Azacycle - Ether - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
External Descriptors hydrochloride - piperidines - cyclic ketone
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ACHE Tclin Acetylcholinesterase (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Cholinesterases; ACHE & BCHE (1222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
SensibilidadMoisture sensitive
Punto de fusión (°C)220-222°C
Peso molecular416.000 g/mol
XLogP3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass415.191 Da
Monoisotopic Mass415.191 Da
Topological Polar Surface Area38.800 Ų
Heavy Atom Count29
Formal Charge0
Complexity510.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Citations of This Product
Referencias
1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li.  (2023)  Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:38052155] [10.1016/j.ejmech.2023.116013]
2. Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu.  (2023)  Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37844366] [10.1016/j.jpba.2023.115765]
3. Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han.  (2022)  Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:35304276] [10.1016/j.jep.2022.115194]
4. Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua.  (2022)  Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.  Frontiers in Aging Neuroscience,      [PMID:35126093] [10.3389/fnagi.2021.809433]
5. Li Ying-Qi, Chen Yi, Jiang Si-Qi, Shi Yuan-Yuan, Jiang Xiao-Li, Wu Shan-Shan, Zhou Ping, Wang Hui-Ying, Li Ping, Li Fei.  (2021)  An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease.  Frontiers in Cell and Developmental Biology,      [PMID:34350171] [10.3389/fcell.2021.652310]
6. Liping Zhao, Ge Yang, Linsen Li, Chao Zhu, Yao Ma, Feng Qu.  (2020)  Aptamer-functionalized magnetic nanoparticles conjugated organic framework for immobilization of acetylcholinesterase and its application in inhibitors screening.  ANALYTICA CHIMICA ACTA,      [PMID:33218485] [10.1016/j.aca.2020.10.024]
7. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li.  (2020)  Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:32173426] [10.1016/j.jep.2020.112764]
8. Min Tao, Li Zhang, Yinlong Guo.  (2018)  Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:30159674] [10.1007/s13361-018-2054-3]
9. Mingfei Wu, Jie Ma, Lijun Ji, Min Wang, Jianfei Han, Zeng Li.  (2019)  Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31136894] [10.1016/j.ejmech.2019.05.055]
10. Yue Chen, Hai-Long Wu, Tong Wang, Ru-Qin Yu.  (2024)  A calibration model transfer method based on quadrilinear model for excitation-emission matrix fluorescence measurements on different fluorescence spectrophotometers.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110053]
11. Donglin Xiang, Shuyi Qiu, Laping He, Chun Ji, Jiayu Chen, Yuangen Wu, Han Tao.  (2024)  Purification, characterization of a plant esterase from red kidney bean and its feasibility for pesticide residue analysis in foods.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.103944]
12. Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou.  (2024)  Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway.  NEUROSCIENCE LETTERS,      [PMID:38616003] [10.1016/j.neulet.2024.137769]
13. Yan-Peng Liang, Qian Gao, Hong Chen, Rui Ma, Xiao-Bo Zhao, Xiao-Jie Jin, Jian Zhang, Yan-Ping Shi, Wei Ha.  (2025)  Multi-target directed ligands design of 1-O-Acetylbritannilactone derivatives: Dual anti-neuroinflammatory and acetylcholinesterase inhibitory activities.  Phytochemistry Letters,      [PMID:] [10.1016/j.phytol.2025.103011]
14. Chen Junyang, Xiang Pan, Duro-Castano Aroa, Cai Huawei, Guo Bin, Liu Xiqin, Yu Yifan, Lui Su, Luo Kui, Ke Bowen, Ruiz-Pérez Lorena, Gong Qiyong, Tian Xiaohe, Battaglia Giuseppe.  (2025)  Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport.  Signal Transduction and Targeted Therapy,  10  (1): (1-12).  [PMID:41052971] [10.1038/s41392-025-02426-1]
15. Zhe Wang, Hao-tian Zhang, Si-yue Li, Xiu-ping Song, Chong-zhen Shi, Ye-wen Zhang, Fei Han.  (2025)  An integrative study on the effects of Lingguizhugan decoction in treating Alzheimer's disease rats through modulation of multiple pathways involving various components.  COMPUTERS IN BIOLOGY AND MEDICINE,      [PMID:40228446] [10.1016/j.compbiomed.2025.110149]
16. Che Chen, Qianfeng Shao, Sheng Zhou.  (2025)  Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology.  Frontiers in Aging Neuroscience,      [PMID:41450541] [10.3389/fnagi.2025.1688316]
17. Amel A. Ibrahim, Nancy M. El Halfawy, Yuqi Zhang, Ya Liu, Xirui Zhang, Shuxin Zhou, Jianquan Kan, Muying Du.  (2025)  Development and Genomic Evaluation of a Novel Functional Fermented Milk Formulated with Lactobacillus delbrueckii Strains and Jujuba Kernel Powder for Potential Neuroprotective Effects.  Foods,  14  (24):   [PMID:41473941] [10.3390/foods14244264]
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20. Zi-Han Xu, Zheng-Biao Zou, Chun-Xiu Wang, Chen Li, Xian-Wen Yang, Jun-Song Wang.  (2026)  Anti-Neuroinflammatory Naphtho-γ-Pyrones from a Deep-Sea-Derived Fungus Aspergillus niger 3A00562.  Marine Drugs,  24  (4): (125).  [PMID:] [10.3390/md24040125]
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