Donepezil hydrochloride monohydrate - Moligand™, 10mM in DMSO , Inhibitor of acetylcholinesterase (Cartwright blood group), CAS No.120014-06-4, Inhibitor of acetylcholinesterase (Cartwright blood group)

CAS: 120014-06-4 Cat. No.: D420884 Peso molecular: 433.97 Número EC: 601-651-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC 737535|DONEPEZIL [MI]|(RS)-2-[(1-BENZYL-4-PIPERIDYL)METHYL]-5,6-DIMETHOXYINDAN-1-ONE|8SSC91326P|SCHEMBL8265876|(+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5,6-DIMETHOXY-1-INDANONE|DONEPEZIL [VANDF]|Z1741977105|2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Sinónimos

NSC 737535 | DONEPEZIL [MI] | (RS)-2-[(1-BENZYL-4-PIPERIDYL)METHYL]-5, 6-DIMETHOXYINDAN-1-ONE | 8SSC91326P | SCHEMBL8265876 | (+/-)-2-((1-BENZYL-4-PIPERIDYL)METHYL)-5, 6-DIMETHOXY-1-INDANONE | DONEPEZIL [VANDF] | Z1741977105 | 2, 3-dihydro-5, 6-dimethoxy-2-((1-(phenylmethyl)

Especificaciones y pureza

Moligand™, 10mM in DMSO

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of acetylcholinesterase (Cartwright blood group)

Nombres e identificadores

• Isómeros SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
• WGK Alemania: 3
• Peso molecular: 433.97
• Reaxy-Rn: 7081955
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7081955&ln=

Objetivos asociados (humanos)

SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (0 Activities)

Discover Target: SIGMAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BACE1 Tchem Beta-secretase 1 (0 Activities)

Discover Target: BACE1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (0 Activities)

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase (0 Activities)

Discover Target: BCHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de inflamación (°F): 49 °C
• Punto de inflamación (°C): 49°C

Referencias

1. Hanzhi Zhang, Chunli Lou, Jing Li, Jingwu Kang.  (2020)  A gold foil covered fused silica capillary tip as a sheathless interface for coupling capillary electrophoresis-mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:32540065] [10.1016/j.chroma.2020.461215]

2. Ting Zhang, Keli Dong, Lan Xiao, Guangcheng Li, Zhanwei Zhang.  (2022)  Effects of Co-Administration of Icariin and Panax notoginseng Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer’s Disease.  Neuropsychiatric Disease and Treatment,      [PMID:33061388] [10.2147/NDT.S253972]

3. Lu Cui, Yu Wang, Zhihong Liu, Hongzhuan Chen, Hao Wang, Xinxin Zhou, Jun Xu.  (2015)  Discovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data.  Journal of Chemical Information and Modeling,      [PMID:26509353] [10.1021/acs.jcim.5b00449]