Dot1L-IN-1 TFA - ≥98% , CAS No.D658712

CAS: D658712 Cat. No.: D658712 Peso molecular: 760.23

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC 50 =3 nM), as well as the activity of the HoxA9 promoter (IC 50 =17 nM) in HeLa and Molm

Appearance:Solid

IC50& Target:DOT1L

In Vitro:Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC 50 =5 nM). MCE has not independently confirmed the accuracy of these methods. They are for

Biological Activity:Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a K i of 2 pM and an IC 50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC 50 =3 nM), as well as the activity of the HoxA9 promoter (IC 50 =17 nM) in HeLa and Molm

Specifications

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 760.23

Propiedades químicas y físicas

• Solubilidad: DMSO : 50 mg/mL (65.77 mM; Need ultrasonic)