DRF-1042 - 10mM in DMSO , CAS No.200619-13-2

CAS: 200619-13-2 Cat. No.: D655919 Peso molecular: 408.40 PubChem CID: 23631031

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype

In Vitro

DRF-1042 demonstrates superior lactone stability and good in vitro anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In clonogenic assay against murine, canine and human bone marrow cells, DRF-1042 treatment shows less mylosupression that supports the possibility of protracted dose schedule in both experimental and clinical studies. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:DNA topoisomerase I

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

DRF-1042 is an orally active derivative of Camptothecin. DRF-1042 acts to inhibit DNA topoisomerase I . DRF-1042 shows good anticancer activity against a panel of human cancer cell lines including multi-agent resistance (MDR) phenotype.

Condiciones de almacenamiento de almacenamiento

Argon charged, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3C(C4=CC5=CC=CC=C5N=C4C3=C2)OCCO)O
• CAS alternativo: 200619-13-2
• PubChem CID: 23631031
• Términos de entrada MeSH: 5-(2'-hydroxyethoxy)-20(S)-camptothecin;DRF-1042;DRF1042
• Peso molecular: 408.40