≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Duloxetine HCl is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) A dual serotonin and norepinephrine reuptake inhibitor
High affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (Kivalues are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC50values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal sli
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
External Descriptors
duloxetine hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Weijun Zhou, Wenyun Zhou, Yonghao Bi, Zibin Zhou, Zhigao Zhou, Shaozhe Chen, Gang Xie, Zhen Lian, Guixin Yuan, Guanfeng Yao. (2023) Antidepressant duloxetine hydrochloride protects against ovariectomy-induced bone loss in mice by inhibiting osteoclast differentiation. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37913736][10.1016/j.biopha.2023.115810]
2.Jingjing Chen, Peipei Li, Yixiu Han, Yuchen Li, Yingxiang Du. (2023) Highly photoluminescent nitrogen-doped carbon quantum dots as a green fluorescence probe for determination of myricetin. FOOD CHEMISTRY, [PMID:36933427][10.1016/j.foodchem.2023.135920]
3.Xiujuan Chen, Chen Liang, Lijun Cui, Jian Le, Zheyuan Qian, Runsheng Zhang, Zhanying Hong, Yifeng Chai. (2018) A rapid LC-MS/MS method for simultaneous determination of quetiapine and duloxetine in rat plasma and its application to pharmacokinetic interaction study. JOURNAL OF FOOD AND DRUG ANALYSIS, [PMID:30648587][10.1016/j.jfda.2018.07.003]
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