Dynasore - ≥98% , CAS No.304448-55-3

CAS: 304448-55-3 Cat. No.: D125461 Peso molecular: 322.31

GRADE & PURITY ≥98%

Synonyms

N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide | cyclohexane-1,4-dicarboxylic acid;1,4-Cyclohexanedicarboxylic Acid | N'-[(3,4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide | EN300-97658 | NCGC00259575-01 | AKOS0

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase
An inhibitor of Dynamin I and Dynamin II

Specifications

Sinónimos

N'-[(E)-(3, 4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide | cyclohexane-1, 4-dicarboxylic acid;1, 4-Cyclohexanedicarboxylic Acid | N'-[(3, 4-dihydroxyphenyl)methylidene]-3-hydroxynaphthalene-2-carbohydrazide | EN300-97658 | NCGC00259575-01 | AKOS0

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Dynasore is a non-competitive, cell-permeable semicarbazone compound inhibitor of Dynamin I and Dynamin II. Members of the Dynamin family, including Dynamin I, Dynamin II and Dynamin III, are GTPase, microtubule-associated proteins which are involved in e

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504773375
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773375
• Sonrisas canónicas: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
• IUPAC Name: N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide
• InChIKey: SYNDQCRDGGCQRZ-VXLYETTFSA-N
• INCHI: 1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
• Isómeros SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O
• Peso molecular: 322.31
• Reaxy-Rn: 20640593
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20640593&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Naphthalenes
      • Subclass Naphthalenecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Naphthalenes
• Subclass: Naphthalenecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Naphthalenecarboxamides
• Alternative Parents: Naphthols and derivatives Salicylic acid and derivatives Catechols 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Carboxylic acids and derivatives Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: 2-naphthalenecarboxamide - 2-naphthol - Salicylic acid or derivatives - Catechol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Monocyclic benzene moiety - Vinylogous acid - Carboxylic acid derivative - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aromatic homopolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as naphthalenecarboxamides. These are compounds containing a naphthalene moiety, which bears a carboxylic acid amide group at one or more positions. Naphthalene is a bicyclic compound that is made up of two fused benzene rings.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

DNM1 Tbio Dynamin-1 (215 Activities)

Discover Target: DNM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DNM2 Tchem Dynamin-2 (62 Activities)

Discover Target: DNM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDC42SE1 Tdark CDC42 small effector protein 1 (3 Activities)

Discover Target: CDC42SE1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

COS-7 (515 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (100 mM), and ethanol (5 mM). Insoluble in water
• Sensibilidad: Heat Sensitive；light sensitive
• Peso molecular: 322.300 g/mol
• XLogP3: 3.600
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 322.095 Da
• Monoisotopic Mass: 322.095 Da
• Topological Polar Surface Area: 102.000 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 470.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Referencias

1. Dan Yuan, Qi Li, Qibo Zhang, Feibai Zhou, Qiangzhong Zhao, Mouming Zhao.  (2023)  Enhanced curcumin transportation across epithelial barrier by mucus-permeable soy protein nanoparticles-mediated dual transcytosis pathways.  FOOD CHEMISTRY,      [PMID:37897825] [10.1016/j.foodchem.2023.137771]

2. Siyuan Huang, Qi Su, Xiaoqiang Hou, Kuankuan Han, Shufang Ma, Bingshe Xu, Yingjun Yang.  (2022)  Influence of Colonies’ Morphological Cues on Cellular Uptake Capacity of Nanoparticles.  Frontiers in Bioengineering and Biotechnology,      [PMID:35711638] [10.3389/fbioe.2022.922159]

3. Wang Huawei, Shan Xiajing, Ren Mengtian, Shang Mengdi, Zhou Chuanzheng.  (2021)  Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis.  NUCLEIC ACIDS RESEARCH,  49  (21): (12306-12319).  [PMID:34865123] [10.1093/nar/gkab1121]

4. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang.  (2021)  Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis.  Advanced Healthcare Materials,  11  (2): (2101926).  [PMID:34738742] [10.1002/adhm.202101926]

5. Zhuqing Dai, Jiangfeng Song, Ye Chen, Lei Feng, Yayuan Xu, Dajing Li, Caie Wu, Zhongyuan Zhang, Jun Liu.  (2021)  Study on the bioavailability of stevioside-encapsulized lutein and its mechanism.  FOOD CHEMISTRY,      [PMID:33756320] [10.1016/j.foodchem.2021.129528]

6. Gao Feng, Shao Tianyi, Yu Yunpeng, Xiong Yujie, Yang Lihua.  (2021)  Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action.  Nature Communications,  12  (1): (1-18).  [PMID:33531505] [10.1038/s41467-021-20965-3]

7. Le Feng, Xiao Xiao, Jing Liu, Junyan Wang, Nan Zhang, Tao Bing, Xiangjun Liu, Ziping Zhang, Dihua Shangguan.  (2020)  Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level.  MOLECULES,  25  (6): (1351).  [PMID:32188121] [10.3390/molecules25061351]

8. Shanshan Wang, Zhangkun Liu, Yuxiu Zou, Xiaofang Lai, Ding Ding, Long Chen, Liqin Zhang, Yuan Wu, Zhuo Chen, Weihong Tan.  (2016)  Elucidating the cellular uptake mechanism of aptamer-functionalized graphene-isolated-Au-nanocrystals with dual-modal imaging.  ANALYST,  141  (11): (3337-3342).  [PMID:27111129] [10.1039/C6AN00483K]

9. Liu Di, Guo Hua, Zheng Wenyun, Zhang Na, Wang Tianwen, Wang Ping, Ma Xingyuan.  (2016)  Discovery of the cell-penetrating function of A2 domain derived from LTA subunit of Escherichia coli heat-labile enterotoxin.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  100  (11): (5079-5088).  [PMID:26960316] [10.1007/s00253-016-7423-x]

10. Jiabin Zhang, Xiaodie Chen, Yurong Chai, Yuanyuan Jin, Fenfang Li, Chenya Zhuo, Yanteng Xu, Haixia Wang, Enguo Ju, Yeh-Hsing Lao, Xi Xie, Mingqiang Li, Yu Tao.  (2025)  Mesenchymal stromal/stem cell spheroid-derived extracellular vesicles advance the therapeutic efficacy of 3D-printed vascularized artificial liver lobules in liver failure treatment.  Bioactive Materials,      [PMID:40124595] [10.1016/j.bioactmat.2025.02.042]

11. Min Mu, Hui Li, Susu Xiao, Chenqian Feng, Bo Chen, Rangrang Fan, Nianyong Chen, Gang Guo.  (2025)  Spatiotemporal-Controlled Nanoagonists Triggered STING Activation for Cascade-Amplified Photothermal Metalloimmunotherapy.  BIOMACROMOLECULES,      [PMID:40629961] [10.1021/acs.biomac.4c01774]

12. Zhuo Zhang, Mingchen Lv, Jiaxi Xu, Yaping Liu, Jinlong Qin, Zhen Fan, Jianzhong Du.  (2025)  A Metal-Peptide Framework as a Nanozyme for the Attenuation of Amyloid-β Aggregation and Reactive Oxygen Species.  JACS Au,      [PMID:41001643] [10.1021/jacsau.5c00721]