(E)-[6]-Dehydroparadol - 10mM in DMSO , CAS No.878006-06-5

CAS: 878006-06-5 Cat. No.: D655806 Peso molecular: 276.37 PubChem CID: 6438480

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol , is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells

In Vitro

(E)-[6]-Dehydroparadol (M15) (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC 50 s of 43.02 and 41.59 µM, respectively. (E)-[6]-Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(E)-[6]-Dehydroparadol (compound 19) (5 µM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Nrf2

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol ( HY-14616 ), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

ACTIVATOR

Nombres e identificadores

• Isómeros SMILES: CCCCCCCC(=O)/C=C/C1=CC(=C(C=C1)O)OC
• PubChem CID: 6438480
• Peso molecular: 276.37