10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Argon charged,Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects
IC50& Target:IC50: 609 nM (NRP1-a1 and NRP1-b)
In Vitro:EG01377 (3-30 μM; 30 minutes) inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR. EG01377 (30 μM) is able to significantly reduce HUVEC cell migration in response to VEGFA. EG01377 (30 μM; 5
In Vivo:EG01377 (2mg/kg; i.v.) exhibits an encouraging half-life of 4.29 h, sufficient to sustain once per day dosing in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week-old BABL/c
Biological Activity:EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) , with a K d of 1.32 μM, and IC 50 s of 609 nM for both NRP1-a1 and NRP1-b1 . EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects
| Peso molecular | 659.6 |
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Comprehensive hazard, handling, storage, and regulatory compliance document.
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