EHT 1864 2HCl - 10mM in DMSO , CAS No.754240-09-0

CAS: 754240-09-0 Cat. No.: E408927 Peso molecular: 581.47 Número EC: 695-652-1 PubChem CID: 9938202

GRADE & PURITY 10mM in DMSO

Synonyms

2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
In vitro

EHT 1864 selectively inhibits Rac-induced lamellipodia formation, and specifically reverses cell transformation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down.

In vivo

EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.
Cell Data

cell lines：

Concentrations：~5 μM

Incubation Time：4 days

Powder Purity:≥99%

Specifications

Sinónimos

2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one, hydrochloride (1:2)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K_d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl
• WGK Alemania: 3
• PubChem CID: 9938202
• Peso molecular: 581.47

Referencias

1. Yuyao Jiang, Yanru Guan, Ruidong Chen, Jason T. Magnuson, Wen Zexin, Zijie Ding, Leyi Zhang, Wumuerzati Maermaer, Yuanyuan Liu, Shuying Li, Wenjun Gui, Daniel Schlenk.  (2025)  Chlorpyrifos cardiotoxic responses may be mediated by phagocytic activation in larval zebrafish.  Environmental Chemistry and Ecotoxicology,      [PMID:] [10.1016/j.enceco.2025.12.001]