Elastase from Human Neutrophil, CAS No.9004-06-2

CAS: 9004-06-2 Cat. No.: np001098 Número EC: 232-670-7
Disponible para pedir
GRADE & PURITY Bioactive ? Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure. ActiBioPure™ ? ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required. High Performance ? High-performance grade with optimized purity and performance characteristics. Use for sensitive analyses where ordinary grades fall short. EnzymoPure™ ? EnzymoPure™ — Aladdin's line of high-quality enzymatic solutions. Use when enzyme purity and defined activity drive assay or process performance. ≥95%(SDS-PAGE) Pre-lyophilization Protein Concentration
Accession #
P08246
Bioactivity
20-22 U/mg protein
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
25μg
np001098-25μg
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
599,90US$
100μg
np001098-100μg
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
1.999,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

ActiBioPure™, Bioactive, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration ActiBioPure™,Bioactive,High Performance,EnzymoPure™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 12 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

Specifications

Product Name
Elastase from Human Neutrophil, CAS No.9004-06-2
Sinónimos
Bone marrow serine protease | EC 3.4.21 | EC 3.4.21.37 | ELA2 | granulocyte-derived elastase | ELANE | elastase 2 | neutrophil | elastase | neutrophil expressed | Elastase-2 | GE | HNE | Human leukocyte elastase | Leukocyte Elastase | Medullasin | NE | Ne
Grado
ActiBioPure™, Bioactive, High Performance, EnzymoPure™
Especificaciones y pureza
ActiBioPure™, Bioactive, High Performance, EnzymoPure™, ≥95%(SDS-PAGE), Pre-lyophilization Protein Concentration
Mecanismos bioquímicos y fisiológicos
Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Throug
Bioactividad
20-22 U/mg protein
Número de adhesión
Peso molecular previsto
29.5 kDa
CAS
9004-06-2
Número de la Comisión de Enzimas
3.4.21.37
Tipo de molécula
Enzyme
Almacenamiento y envío
Forma
Salt-free lyophilized solid.
Concentración
Pre-lyophilization Protein Concentration
Reconstitución
After centrifugation, we suggest addition of 52.1 uL of 50 mM Na Acetate, pH 5.5, with 150 mMNaCl to the original volume (See COA), followed by gentle mixingto ensure adequate homogenization.
Condiciones de almacenamiento de almacenamiento
Store at -20°C,Avoid repeated freezing and thawing
Enviado en
Ice chest + Ice pads
Estabilidad y almacenamiento
Store at -20℃ long term (>1 year). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle.
Definición de unidad
One unit is defined as the amount of enzyme which hydrolyzes one umole of Meo-suc-ala-ala-pro-val-pNA per minute at 25oC in 100 mMTris-HCl, pH 7.5, with 500 mMNaCl.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeFechaArticulo
ZJ26F0333379Certificate of AnalysisMar 25, 2026 np001098
ZJ25F1230379Certificate of AnalysisDec 22, 2025 np001098
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Jin Zhang, Chunsheng Xiao, Xi Zhang, Yandai Lin, Huanghao Yang, Yu Shrike Zhang, Jianxun Ding.  (2021)  An oxidative stress-responsive electrospun polyester membrane capable of releasing anti-bacterial and anti-inflammatory agents for postoperative anti-adhesion.  JOURNAL OF CONTROLLED RELEASE,      [PMID:33895199] [10.1016/j.jconrel.2021.04.017]
2. Zhang Huaiyu, Zhang Jiayu, Liu Yilun, Jiang Yang, Li Zhongmin.  (2021)  Molecular Targeted Agent and Immune Checkpoint Inhibitor Co-Loaded Thermosensitive Hydrogel for Synergistic Therapy of Rectal Cancer.  Frontiers in Pharmacology,      [PMID:33935796] [10.3389/fphar.2021.671611]
3. Qiu Renna, Li Jian, Sun Denghua, Li Hongjun, Qian Feng, Wang Lizhe.  (2019)  20(S)-Ginsenoside Rg3-loaded electrospun membranes to prevent postoperative peritoneal adhesion.  BIOMEDICAL MICRODEVICES,  21  (4): (1-11).  [PMID:31414228] [10.1007/s10544-019-0425-6]
4. Wenjing Zhang, Weiguo Xu, Cong Ning, Mingqiang Li, Guoqing Zhao, Weiqian Jiang, Jianxun Ding, Xuesi Chen.  (2018)  Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia.  BIOMATERIALS,      [PMID:30099261] [10.1016/j.biomaterials.2018.07.051]
5. Gao Zhen, Wang Jing, Jing Jing, Dan Xu, Li Zheng, Fengsen Li.  (2018)  Effects of Modified Zhisou Powder on Airway Mucus Production in Chronic Obstructive Pulmonary Disease Model Rats with Cold-Dryness Syndrome.  Evidence-based Complementary and Alternative Medicine,      [PMID:30105060] [10.1155/2018/7297141]
6. Wenjing Zhang, Cong Ning, Weiguo Xu, Hanze Hu, Mingqiang Li, Guoqing Zhao, Jianxun Ding, Xuesi Chen.  (2018)  Precision-guided long-acting analgesia by Gel-immobilized bupivacaine-loaded microsphere.  Theranostics,      [PMID:29930733] [10.7150/thno.25276]
7. Jiannan Li, Xiangru Feng, Jian Shi, Tongjun Liu, Jianxun Ding.  (2018)  Porous Polylactide Film Plus Atorvastatin-Loaded Thermogel as an Efficient Device for Peritoneal Adhesion Prevention.  ACS Omega,      [PMID:30023849] [10.1021/acsomega.8b00090]
8. Jiannan Li, Weiguo Xu, Jinjin Chen, Di Li, Kai Zhang, Tongjun Liu, Jianxun Ding, Xuesi Chen.  (2017)  Highly Bioadhesive Polymer Membrane Continuously Releases Cytostatic and Anti-Inflammatory Drugs for Peritoneal Adhesion Prevention.  ACS Biomaterials Science & Engineering,      [PMID:33445273] [10.1021/acsbiomaterials.7b00605]
9. Xuezhou Li, Jianxun Ding, Zhengzheng Zhang, Modi Yang, Jiakuo Yu, Jincheng Wang, Fei Chang, Xuesi Chen.  (2016)  Kartogenin-Incorporated Thermogel Supports Stem Cells for Significant Cartilage Regeneration.  ACS Applied Materials & Interfaces,      [PMID:26844837] [10.1021/acsami.5b12212]
10. Song Zhiming, Shi Bo, Ding Jianxun, Zhuang Xiuli, Zhang Xiaonan, Fu Changfeng, Chen Xuesi.  (2015)  A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics.  Science China-Chemistry,  58  (7): (1159-1168).  [PMID:] [10.1007/s11426-015-5425-7]
11. Song Zhi-ming, Shi Bo, Ding Jian-xun, Zhuang Xiu-li, Zhang Xiao-nan, Fu Chang-feng, Chen Xue-si.  (2015)  Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide).  CHINESE JOURNAL OF POLYMER SCIENCE,  33  (4): (587-596).  [PMID:] [10.1007/s10118-015-1611-5]
12. Le-Yu Huang, Huiling Wang, Yue-Yang Zhang, Shi-Yu Liu.  (2025)  An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:40188572] [10.1016/j.saa.2025.126152]
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