Emricasan (IDN-6556) - Moligand™, 10mM in DMSO , Caspase inhibitor, CAS No.254750-02-2, Caspase inhibitor

CAS: 254750-02-2 Cat. No.: E409139 Peso molecular: 569.51

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1,​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2,​3,​5,​6-​tetrafluorophenoxy)​propyl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Emricasan (IDN-6556) Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.
In vitro

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

In vivo

Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.
Cell Data

cell lines：

Concentrations：9 μM

Incubation Time：1 h

Powder Purity:≥98%

Specifications

Sinónimos

PF 03491390, PF-03491390 | L-​Alaninamide, N-​[2-​(1, ​1-​dimethylethyl)​phenyl]​-​2-​oxoglycyl-​N-​[(1S)​-​1-​(carboxymethyl)​-​2-​oxo-​3-​(2, ​3, ​5, ​6-​tetrafluorophenoxy)​propyl]​-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Caspase inhibitor

Propiedades del producto

• ALogP: 3.6

Nombres e identificadores

• Isómeros SMILES: C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
• Peso molecular: 569.51
• Reaxy-Rn: 10047524
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10047524&ln=

Objetivos asociados (humanos)

CASP8 Tchem Caspase-8 (1 Activities)

Discover Target: CASP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CASP3 Tchem Caspase-3 (1 Activities)

Discover Target: CASP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (164.03 mM); Water: Insoluble; Ethanol: Insoluble