EN460 - 10mM in DMSO , CAS No.496807-64-8

CAS: 496807-64-8 Cat. No.: E655310 Fórmula: C₂₂H₁₂ClF₃N₂O₄ Peso molecular: 460.79 PubChem CID: 1016023

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

In Vitro

Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 ( IC 50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

Isómeros SMILES

C1=CC=C(C=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC(=C(C=C4)Cl)C(=O)O)C(F)(F)F

PubChem CID

1016023

Peso molecular

460.79