Erythromycin Ethylsuccinate - 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.1264-62-6, Bacterial 70S ribosome inhibitor

CAS: 1264-62-6 Cat. No.: E408903 Peso molecular: 862.05 Número EC: 215-033-8

GRADE & PURITY 10mM in DMSO

Synonyms

Erythromycin, 2-(ethyl butanedioate)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced byStreptomyces erythreus, reversibly binds to the50S ribosomeof bacteria, and inhibits protein synthesis.
In vitro

Erythromycin displays antibacterial activity against Staphylococcus aureus, streptococcus pneumonia, Streptococcus pyogenes, Haemophilus influenza, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Campylobacter jejuni, Helicobacter pylori, and Borrelia burgdorferi. Erythromycin is a motilin receptor agonist, which is a potent stimulator of gastrointestinal motor activity. The concentrations of Erythromycin required to induce 50% of the maximum contractile response to a supramaximal dose of acetylcholine is 2 μM. The concentrations of Erythromycin required to displace 50% of the labeled motilin is 13 μM. Erythromycin has no effect on muscle strips of rat or dog duodenum but induces contractions in human strips.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Sinónimos

Erythromycin, 2-(ethyl butanedioate)

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Bacterial 70S ribosome inhibitor

Propiedades del producto

• ALogP: 3.4

Nombres e identificadores

• Isómeros SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)OC(=O)CCC(=O)OCC)(C)O)C)C)O)(C)O
• WGK Alemania: 2
• RTECS: WM9800000
• Peso molecular: 862.05
• Reaxy-Rn: 28936360
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28936360&ln=

Referencias

1. Pengcheng Xing, Di Wu, Jingshuai Chen, Jiming Song, Changjie Mao, Yuanhao Gao, Helin Niu.  (2019)  A Cd-MOF as a fluorescent probe for highly selective, sensitive and stable detection of antibiotics in water.  ANALYST,  144  (8): (2656-2661).  [PMID:30843538] [10.1039/C8AN02442A]